Assay Detail
Binding
CHEMBL4810784
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IDO1 in human HeLa cells assessed as production of N-formylkynurenine using tryptophan as substrate in presence of inactivated fetal bovine serum
42
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of IDO1 inhibitors containing a decahydroquinoline, decahydro-1,6-naphthyridine, or octahydro-1H-pyrrolo[3,2-c]pyridine scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 7.92 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4855797 | — | — | 4 | 9.00 |
| CHEMBL4858599 | — | — | 4 | 8.82 |
| CHEMBL4848630 | — | — | 4 | 8.80 |
| CHEMBL4863767 | — | — | 4 | 8.72 |
| CHEMBL4848366 | — | — | 4 | 8.72 |
| CHEMBL4852537 | — | — | 2 | 8.70 |
| CHEMBL4849622 | — | — | 4 | 8.62 |
| CHEMBL4853448 | — | — | 4 | 8.54 |
| CHEMBL4847151 | — | — | 4 | 8.44 |
| CHEMBL4861395 | — | — | 1 | 8.41 |
| CHEMBL4849825 | — | — | 4 | 7.96 |
| CHEMBL3545369 | EPACADOSTAT | 3.0 | 1 | 7.90 |
| CHEMBL4857208 | — | — | 2 | 5.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4855797 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4858599 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4848630 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4848366 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4863767 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4863767 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4855797 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4852537 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4855797 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4855797 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL4849622 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4863767 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4853448 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4849622 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4863767 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4847151 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL4848366 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4861395 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL4852537 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL4848630 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL4848630 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL4847151 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL4849622 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4848366 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL4849825 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4853448 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3545369 | EPACADOSTAT | IC50 | = | 12.5 | nM | 7.90 |
| CHEMBL4849622 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4847151 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4849825 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4858599 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4848366 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4848630 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4853448 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4858599 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL4858599 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL4849825 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL4853448 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL4847151 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4857208 | — | IC50 | = | 1052.0 | nM | 5.98 |
| CHEMBL4849825 | — | IC50 | = | 1149.0 | nM | 5.94 |
| CHEMBL4857208 | — | IC50 | = | 27702.0 | nM | 4.56 |