Assay Detail
Binding
CHEMBL4810787
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Inhibition of IDO1 in human whole blood assessed as unbound concentration
11
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of IDO1 inhibitors containing a decahydroquinoline, decahydro-1,6-naphthyridine, or octahydro-1H-pyrrolo[3,2-c]pyridine scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 9.44 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4863767 | — | — | 1 | 10.00 |
| CHEMBL4855797 | — | — | 2 | 9.89 |
| CHEMBL4848630 | — | — | 1 | 9.54 |
| CHEMBL4848366 | — | — | 2 | 9.14 |
| CHEMBL4858599 | — | — | 1 | 9.07 |
| CHEMBL4849622 | — | — | 1 | 9.01 |
| CHEMBL4853448 | — | — | 1 | - |
| CHEMBL4847151 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4863767 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL4855797 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL4848630 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL4848366 | — | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL4858599 | — | IC50 | = | 0.86 | nM | 9.07 |
| CHEMBL4849622 | — | IC50 | = | 0.98 | nM | 9.01 |
| CHEMBL4855797 | — | IC50 | - | — | - | |
| CHEMBL4848366 | — | IC50 | - | — | - | |
| CHEMBL4853448 | — | IC50 | - | — | - | |
| CHEMBL4847151 | — | IC50 | - | — | - | |
| CHEMBL4847151 | — | IC50 | - | — | - |