Assay Detail
Functional
CHEMBL4810888
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Antiproliferation activity against human MCF7 cells assessed as reduction in cell viability measured by CellTiter-Glo luminescent assay assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of GNE-502 as an orally bioavailable and potent degrader for estrogen receptor positive breast cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 9.30 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4877968 | — | — | 1 | 9.40 |
| CHEMBL4851830 | — | — | 1 | 9.30 |
| CHEMBL4849978 | — | — | 1 | 9.30 |
| CHEMBL4649161 | — | — | 1 | 9.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4877968 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4851830 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4849978 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4649161 | — | IC50 | = | 0.66 | nM | 9.18 |