Assay Detail
Functional
CHEMBL4811093
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Antimalarial activity against chloroquine-sensitive plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition measured after 72 hrs by SYBR green dye based fluorescence analysis
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Cell Type | Erythrocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Preparation, biological & cheminformatics-based assessment of N<sup>2</sup>,N<sup>4</sup>-diphenylpyrimidine-2,4-diamine as potential Kinase-targeted antimalarials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 5.92 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 8.40 |
| CHEMBL172 | (S,R)-MEFLOQUINE | — | 1 | 7.85 |
| CHEMBL307261 | ARTENIMOL | 3.0 | 1 | 7.51 |
| CHEMBL527864 | — | — | 1 | 7.40 |
| CHEMBL189862 | — | — | 1 | 6.92 |
| CHEMBL4850121 | — | — | 1 | 6.38 |
| CHEMBL4869308 | — | — | 1 | 6.22 |
| CHEMBL4858727 | — | — | 1 | 6.18 |
| CHEMBL4855763 | — | — | 1 | 6.11 |
| CHEMBL4855061 | — | — | 1 | 6.11 |
| CHEMBL4852173 | — | — | 1 | 6.06 |
| CHEMBL4869819 | — | — | 1 | 6.01 |
| CHEMBL4854098 | — | — | 1 | 5.96 |
| CHEMBL4879064 | — | — | 1 | 5.85 |
| CHEMBL4874210 | — | — | 1 | 5.80 |
| CHEMBL4858018 | — | — | 1 | 5.70 |
| CHEMBL4857511 | — | — | 1 | 5.66 |
| CHEMBL4854275 | — | — | 1 | 5.62 |
| CHEMBL4848690 | — | — | 1 | 5.60 |
| CHEMBL4873694 | — | — | 1 | 5.60 |
| CHEMBL4875807 | — | — | 1 | 5.58 |
| CHEMBL4857289 | — | — | 1 | 5.55 |
| CHEMBL4855638 | — | — | 1 | 5.50 |
| CHEMBL4845852 | — | — | 1 | 5.50 |
| CHEMBL4869115 | — | — | 1 | 5.44 |
| CHEMBL4846172 | — | — | 1 | 5.38 |
| CHEMBL4847999 | — | — | 1 | 5.38 |
| CHEMBL4858355 | — | — | 1 | 5.27 |
| CHEMBL4874204 | — | — | 1 | 5.09 |
| CHEMBL4866479 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL172 | (S,R)-MEFLOQUINE | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL307261 | ARTENIMOL | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL527864 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL189862 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4850121 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4869308 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4858727 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL4855763 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4855061 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL4852173 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL4869819 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL4854098 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4879064 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4874210 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4858018 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4857511 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4854275 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4848690 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4873694 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4875807 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4857289 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4855638 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4845852 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4869115 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4846172 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4847999 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4858355 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL4874204 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL4866479 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL4849865 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3819014 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4879046 | — | IC50 | = | 19000.0 | nM | 4.72 |