Assay Detail
Functional
CHEMBL4811591
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against drug-sensitive asexual intraerythrocytic stage of Plasmodium falciparum 3D7 infected in human O+ erythrocytes assessed as inhibition of parasite growth incubated for 48 hrs followed by addition of [3H]hypoxanthine for 24 hrs by [3H]hypoxanthine incorporation assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Cell Type | Erythrocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Investigation of the in vitro and in vivo efficacy of peptoid-based HDAC inhibitors with dual-stage antiplasmodial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.10 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 8.15 |
| CHEMBL4853947 | — | — | 1 | 8.10 |
| CHEMBL4849568 | — | — | 1 | 7.80 |
| CHEMBL4868526 | — | — | 1 | 7.62 |
| CHEMBL4862927 | — | — | 1 | 7.55 |
| CHEMBL4854577 | — | — | 1 | 7.47 |
| CHEMBL4847978 | — | — | 1 | 7.16 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.16 |
| CHEMBL4873872 | — | — | 1 | 7.12 |
| CHEMBL4858841 | — | — | 1 | 7.00 |
| CHEMBL4854335 | — | — | 1 | 6.90 |
| CHEMBL4878499 | — | — | 1 | 6.85 |
| CHEMBL4866446 | — | — | 1 | 6.79 |
| CHEMBL4873978 | — | — | 1 | 6.67 |
| CHEMBL4851776 | — | — | 1 | 6.67 |
| CHEMBL4849235 | — | — | 1 | 6.55 |
| CHEMBL4878538 | — | — | 1 | 6.29 |
| CHEMBL4868592 | — | — | 1 | 5.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4853947 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4849568 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4868526 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4862927 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4854577 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4847978 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4873872 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL4858841 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL4854335 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL4878499 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL4866446 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL4873978 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL4851776 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL4849235 | — | IC50 | = | 281.0 | nM | 6.55 |
| CHEMBL4878538 | — | IC50 | = | 509.0 | nM | 6.29 |
| CHEMBL4868592 | — | IC50 | = | 1040.0 | nM | 5.98 |