Assay Detail
Binding
CHEMBL4811722
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response by two-electrode voltage-clamp method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | Oocyte |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha3/beta4 (CHEMBL1907593) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Computational and Functional Mapping of Human and Rat α6β4 Nicotinic Acetylcholine Receptors Reveals Species-Specific Ligand-Binding Motifs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.87 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4869892 | — | — | 1 | 6.64 |
| CHEMBL4871260 | — | — | 1 | 5.92 |
| CHEMBL3104239 | — | — | 1 | 5.82 |
| CHEMBL4867647 | — | — | 1 | 5.11 |
| CHEMBL4872191 | — | — | 1 | - |
| CHEMBL4865866 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4869892 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4871260 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3104239 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4867647 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL4872191 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4865866 | — | IC50 | > | 10000.0 | nM | - |