Assay Detail
Functional
CHEMBL4811769
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Immunosuppressive activity in C57BL/6J mouse CD4+ve T cells assessed as inhibition of CD3/CD28-stimulated CD4+ve T cell proliferation incubated for 72 hrs by CellTrace-violet staining based flow cytometry analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | CD4+ve Th |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Biosynthesis of Nonimmunosuppressive ProlylFK506 Analogues with Neurite Outgrowth and Synaptogenic Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.00 | 10.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269732 | TACROLIMUS ANHYDROUS | 4.0 | 1 | 10.47 |
| CHEMBL4877265 | — | — | 1 | 5.40 |
| CHEMBL4876168 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269732 | TACROLIMUS ANHYDROUS | IC50 | = | 0.034 | nM | 10.47 |
| CHEMBL4877265 | — | IC50 | = | 3969.0 | nM | 5.40 |
| CHEMBL4876168 | — | IC50 | = | 7273.0 | nM | 5.14 |