Assay Detail
Functional
CHEMBL4812134
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against amastigote form of Leishmania infantum MHOM/MA(BE)/67 infected in Swiss mouse peritoneal macrophages assessed as reduction in parasite growth treated at 2 hrs post-infection and measured after 5 days by Giemsa staining based microscopic analysis
80
Total Activities
80
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania infantum |
| Cell Type | Peritoneal macrophage |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Revisiting Pyrazolo[3,4-<i>d</i>]pyrimidine Nucleosides as Anti-<i>Trypanosoma cruzi</i> and Antileishmanial Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 80 | 5.01 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4846834 | — | — | 1 | 7.10 |
| CHEMBL388593 | — | — | 1 | 6.75 |
| CHEMBL4853515 | — | — | 1 | 6.60 |
| CHEMBL4573679 | — | — | 1 | 5.97 |
| CHEMBL4879324 | — | — | 1 | 5.70 |
| CHEMBL1467 | ALLOPURINOL | 4.0 | 1 | 5.46 |
| CHEMBL1688966 | — | — | 1 | 5.18 |
| CHEMBL4866769 | — | — | 1 | 5.17 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 5.13 |
| CHEMBL4857392 | — | — | 1 | 5.10 |
| CHEMBL4850284 | — | — | 1 | 5.09 |
| CHEMBL4854628 | — | — | 1 | 4.98 |
| CHEMBL4849951 | — | — | 1 | 4.90 |
| CHEMBL4866244 | — | — | 1 | 4.65 |
| CHEMBL4867373 | — | — | 1 | 4.62 |
| CHEMBL4441282 | — | — | 1 | 4.59 |
| CHEMBL4851843 | — | — | 1 | 4.59 |
| CHEMBL4849515 | — | — | 1 | 4.53 |
| CHEMBL4850814 | — | — | 1 | 4.50 |
| CHEMBL4872012 | — | — | 1 | 4.49 |
| CHEMBL4854614 | — | — | 1 | 4.49 |
| CHEMBL4867530 | — | — | 1 | 4.37 |
| CHEMBL4848328 | — | — | 1 | 4.31 |
| CHEMBL4847325 | — | — | 1 | 4.29 |
| CHEMBL4862547 | — | — | 1 | 4.29 |
| CHEMBL4863097 | — | — | 1 | 4.28 |
| CHEMBL4858079 | — | — | 1 | 4.24 |
| CHEMBL4862065 | — | — | 1 | - |
| CHEMBL4861891 | — | — | 1 | - |
| CHEMBL4870347 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4846834 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL388593 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4853515 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4573679 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL4879324 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1467 | ALLOPURINOL | IC50 | = | 3510.0 | nM | 5.46 |
| CHEMBL1688966 | — | IC50 | = | 6660.0 | nM | 5.18 |
| CHEMBL4866769 | — | IC50 | = | 6820.0 | nM | 5.17 |
| CHEMBL125 | MILTEFOSINE | IC50 | = | 7470.0 | nM | 5.13 |
| CHEMBL4857392 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4850284 | — | IC50 | = | 8110.0 | nM | 5.09 |
| CHEMBL4854628 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL4849951 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL4866244 | — | IC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL4867373 | — | IC50 | = | 24100.0 | nM | 4.62 |
| CHEMBL4441282 | — | IC50 | = | 25400.0 | nM | 4.59 |
| CHEMBL4851843 | — | IC50 | = | 25400.0 | nM | 4.59 |
| CHEMBL4849515 | — | IC50 | = | 29400.0 | nM | 4.53 |
| CHEMBL4850814 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL4872012 | — | IC50 | = | 32700.0 | nM | 4.49 |
| CHEMBL4854614 | — | IC50 | = | 32500.0 | nM | 4.49 |
| CHEMBL4867530 | — | IC50 | = | 43100.0 | nM | 4.37 |
| CHEMBL4848328 | — | IC50 | = | 49400.0 | nM | 4.31 |
| CHEMBL4847325 | — | IC50 | = | 50800.0 | nM | 4.29 |
| CHEMBL4862547 | — | IC50 | = | 50800.0 | nM | 4.29 |
| CHEMBL4863097 | — | IC50 | = | 52800.0 | nM | 4.28 |
| CHEMBL4858079 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL4859043 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4860137 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4870178 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4848830 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4871690 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4872365 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4872889 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4869192 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4846810 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4850164 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4853064 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4866226 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4854372 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4847088 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4848164 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4865117 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4870841 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4879116 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4862443 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4859940 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4870347 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4861891 | — | IC50 | >= | 50800.0 | nM | - |
| CHEMBL4862065 | — | IC50 | > | 64000.0 | nM | - |