Assay Detail
Binding
CHEMBL4812203
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human Gal4 fused PPARgamma LBD expressed in COS-7 cells incubated for 24 hrs by firefly luciferase reporter gene assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, and biological evaluation of a novel dual peroxisome proliferator-activated receptor alpha/delta agonist for the treatment of diabetic kidney disease through anti-inflammatory mechanisms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 5.61 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4875481 | — | — | 1 | 6.00 |
| CHEMBL4853930 | — | — | 1 | 5.79 |
| CHEMBL4872726 | — | — | 1 | 5.76 |
| CHEMBL3707395 | ELAFIBRANOR | 4.0 | 1 | 5.55 |
| CHEMBL4872922 | — | — | 1 | 5.38 |
| CHEMBL4856271 | — | — | 1 | 5.20 |
| CHEMBL4861167 | — | — | 1 | - |
| CHEMBL4860504 | — | — | 1 | - |
| CHEMBL4873389 | — | — | 1 | - |
| CHEMBL4853743 | — | — | 1 | - |
| CHEMBL4852230 | — | — | 1 | - |
| CHEMBL4859752 | — | — | 1 | - |
| CHEMBL4847495 | — | — | 1 | - |
| CHEMBL4869134 | — | — | 1 | - |
| CHEMBL4848052 | — | — | 1 | - |
| CHEMBL4855296 | — | — | 1 | - |
| CHEMBL4869342 | — | — | 1 | - |
| CHEMBL21241 | GW7647 | — | 1 | - |
| CHEMBL38943 | GW501516 | 2.0 | 1 | - |
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4875481 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4853930 | — | EC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL4872726 | — | EC50 | = | 1720.0 | nM | 5.76 |
| CHEMBL3707395 | ELAFIBRANOR | EC50 | = | 2790.0 | nM | 5.55 |
| CHEMBL4872922 | — | EC50 | = | 4220.0 | nM | 5.38 |
| CHEMBL4856271 | — | EC50 | = | 6360.0 | nM | 5.20 |
| CHEMBL4861167 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4860504 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4873389 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4853743 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4852230 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4859752 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4847495 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4869134 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4848052 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4855296 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4869342 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL21241 | GW7647 | EC50 | - | — | - | |
| CHEMBL38943 | GW501516 | EC50 | - | — | - | |
| CHEMBL121 | ROSIGLITAZONE | EC50 | = | 191500.0 | nM | - |