Assay Detail
Binding
CHEMBL4812286
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Inhibition of human HDAC6 preincubated for 15 mins followed by substrate addition by fluorescence-based assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of brain penetrant benzazepine-based histone deacetylase 6 inhibitors for alleviating stroke-induced brain infarction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.61 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4858994 | — | — | 1 | 8.74 |
| CHEMBL4854123 | — | — | 1 | 8.25 |
| CHEMBL4873296 | — | — | 1 | 8.21 |
| CHEMBL4847454 | — | — | 1 | 8.19 |
| CHEMBL4858810 | — | — | 1 | 8.19 |
| CHEMBL2364628 | RICOLINOSTAT | 2.0 | 1 | 8.17 |
| CHEMBL4875748 | — | — | 1 | 8.09 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.92 |
| CHEMBL4854768 | — | — | 1 | 7.92 |
| CHEMBL4876815 | — | — | 1 | 7.89 |
| CHEMBL4860396 | — | — | 1 | 7.85 |
| CHEMBL4875969 | — | — | 1 | 7.85 |
| CHEMBL4862139 | — | — | 1 | 7.72 |
| CHEMBL4871812 | — | — | 1 | 7.66 |
| CHEMBL4858918 | — | — | 1 | 7.54 |
| CHEMBL4856735 | — | — | 1 | 7.43 |
| CHEMBL4857891 | — | — | 1 | 7.37 |
| CHEMBL4862419 | — | — | 1 | 7.35 |
| CHEMBL4853358 | — | — | 1 | 7.00 |
| CHEMBL4854716 | — | — | 1 | 6.96 |
| CHEMBL4878252 | — | — | 1 | 6.89 |
| CHEMBL4848981 | — | — | 1 | 6.59 |
| CHEMBL4849884 | — | — | 1 | 6.50 |
| CHEMBL4849225 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4858994 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4854123 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL4873296 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL4847454 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL4858810 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL2364628 | RICOLINOSTAT | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL4875748 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4854768 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4876815 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4860396 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4875969 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4862139 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4871812 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4858918 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4856735 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4857891 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4862419 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4853358 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4854716 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL4878252 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL4848981 | — | IC50 | = | 255.0 | nM | 6.59 |
| CHEMBL4849884 | — | IC50 | = | 318.0 | nM | 6.50 |
| CHEMBL4849225 | — | IC50 | = | 497.0 | nM | 6.30 |