Assay Detail
Functional
CHEMBL4812779
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Antiplasmodial activity against Plasmodium falciparum Uganda field isolated from patients infected in human erythrocytes assessed as parasite killing using albumax media measured after 72 hrs by SYBR Green assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.13 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1956291 | — | — | 1 | 8.43 |
| CHEMBL4850393 | — | — | 1 | 8.01 |
| CHEMBL4848632 | — | — | 1 | 7.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1956291 | — | EC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4850393 | — | EC50 | = | 9.8 | nM | 8.01 |
| CHEMBL4848632 | — | EC50 | = | 11.0 | nM | 7.96 |