Assay Detail
Binding
CHEMBL4812791
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Inhibition of human MAO-B
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel 1-(prop-2-yn-1-ylamino)-2,3-dihydro-1H-indene-4-thiol derivatives as potent selective human monoamine oxidase B inhibitors: Design, SAR development, and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.52 | 9.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4861804 | — | — | 1 | 9.46 |
| CHEMBL4860050 | — | — | 1 | 8.33 |
| CHEMBL887 | RASAGILINE | 4.0 | 1 | 8.22 |
| CHEMBL396778 | SAFINAMIDE | 4.0 | 1 | 7.01 |
| CHEMBL4868008 | — | — | 1 | 5.88 |
| CHEMBL4868937 | — | — | 1 | 5.83 |
| CHEMBL4853325 | — | — | 1 | 5.81 |
| CHEMBL4875992 | — | — | 1 | 5.72 |
| CHEMBL4873465 | — | — | 1 | 5.61 |
| CHEMBL4850189 | — | — | 1 | 5.58 |
| CHEMBL4866653 | — | — | 1 | 5.55 |
| CHEMBL4864573 | — | — | 1 | 5.50 |
| CHEMBL4877335 | — | — | 1 | 5.49 |
| CHEMBL4877043 | — | — | 1 | 5.43 |
| CHEMBL4877328 | — | — | 1 | 5.42 |
| CHEMBL4853169 | — | — | 1 | 5.42 |
| CHEMBL4862202 | — | — | 1 | 5.37 |
| CHEMBL4871606 | — | — | 1 | 5.30 |
| CHEMBL4865811 | — | — | 1 | 5.29 |
| CHEMBL4166555 | — | — | 1 | 5.19 |
| CHEMBL4864153 | — | — | 1 | 5.19 |
| CHEMBL4875936 | — | — | 1 | 5.01 |
| CHEMBL4860189 | — | — | 1 | 4.96 |
| CHEMBL4866427 | — | — | 1 | 4.79 |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 4.69 |
| CHEMBL4857349 | — | — | 1 | 4.63 |
| CHEMBL4851258 | — | — | 1 | 4.59 |
| CHEMBL4854062 | — | — | 1 | 4.54 |
| CHEMBL4874605 | — | — | 1 | 4.52 |
| CHEMBL4858339 | — | — | 1 | 4.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4861804 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL4860050 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL887 | RASAGILINE | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL396778 | SAFINAMIDE | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL4868008 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL4868937 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL4853325 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL4875992 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4873465 | — | IC50 | = | 2430.0 | nM | 5.61 |
| CHEMBL4850189 | — | IC50 | = | 2650.0 | nM | 5.58 |
| CHEMBL4866653 | — | IC50 | = | 2840.0 | nM | 5.55 |
| CHEMBL4864573 | — | IC50 | = | 3190.0 | nM | 5.50 |
| CHEMBL4877335 | — | IC50 | = | 3240.0 | nM | 5.49 |
| CHEMBL4877043 | — | IC50 | = | 3720.0 | nM | 5.43 |
| CHEMBL4853169 | — | IC50 | = | 3850.0 | nM | 5.42 |
| CHEMBL4877328 | — | IC50 | = | 3760.0 | nM | 5.42 |
| CHEMBL4862202 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4871606 | — | IC50 | = | 4950.0 | nM | 5.30 |
| CHEMBL4865811 | — | IC50 | = | 5110.0 | nM | 5.29 |
| CHEMBL4166555 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL4864153 | — | IC50 | = | 6410.0 | nM | 5.19 |
| CHEMBL4875936 | — | IC50 | = | 9680.0 | nM | 5.01 |
| CHEMBL4860189 | — | IC50 | = | 10840.0 | nM | 4.96 |
| CHEMBL4866427 | — | IC50 | = | 16130.0 | nM | 4.79 |
| CHEMBL8706 | CLORGILINE | IC50 | = | 20270.0 | nM | 4.69 |
| CHEMBL4857349 | — | IC50 | = | 23270.0 | nM | 4.63 |
| CHEMBL4851258 | — | IC50 | = | 25780.0 | nM | 4.59 |
| CHEMBL4854062 | — | IC50 | = | 28730.0 | nM | 4.54 |
| CHEMBL4874605 | — | IC50 | = | 30510.0 | nM | 4.52 |
| CHEMBL4858339 | — | IC50 | = | 62010.0 | nM | 4.21 |
| CHEMBL4871614 | — | IC50 | = | 82400.0 | nM | 4.08 |
| CHEMBL4868641 | — | IC50 | = | 85260.0 | nM | 4.07 |
| CHEMBL4871244 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4847352 | — | IC50 | > | 100000.0 | nM | - |