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Assay Detail

CHEMBL4812887

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Trypanosoma cruzi cruzain using Z-FR-AMC as substrate by fluorescence assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Trypanosoma cruzi
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cruzipain (CHEMBL3563)
Type SINGLE PROTEIN
Organism Trypanosoma cruzi

Publication

Nitrile-based peptoids as cysteine protease inhibitors.
Alves L, Santos DA, Cendron R, Rocho FR, Matos TKB, Leitão A, Montanari CA.
Bioorg Med Chem (2021) 41 : 116211 -116211
PubMed 33991733 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 11 5.65 6.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4853021 1 6.80
CHEMBL4463665 1 6.70
CHEMBL4862863 1 6.60
CHEMBL4869083 1 5.60
CHEMBL4873466 1 5.50
CHEMBL4875557 1 5.30
CHEMBL4861436 1 5.20
CHEMBL4846908 1 5.20
CHEMBL4861629 1 5.20
CHEMBL4852162 1 5.10
CHEMBL4857068 1 5.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4853021 Ki = 158.49 nM 6.80
CHEMBL4463665 Ki = 199.53 nM 6.70
CHEMBL4862863 Ki = 251.19 nM 6.60
CHEMBL4869083 Ki = 2511.89 nM 5.60
CHEMBL4873466 Ki = 3162.28 nM 5.50
CHEMBL4875557 Ki = 5011.87 nM 5.30
CHEMBL4861436 Ki = 6309.57 nM 5.20
CHEMBL4846908 Ki = 6309.57 nM 5.20
CHEMBL4861629 Ki = 6309.57 nM 5.20
CHEMBL4852162 Ki = 7943.28 nM 5.10
CHEMBL4857068 Ki = 10000.0 nM 5.00