Assay Detail
Binding
CHEMBL4812898
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition measured for 5 mins by fluorimetric analysis relative to control
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Computer-aided design of 1,4-naphthoquinone-based inhibitors targeting cruzain and rhodesain cysteine proteases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.46 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL374508 | E-64 | — | 1 | 7.70 |
| CHEMBL4877896 | — | — | 1 | 5.20 |
| CHEMBL4845877 | — | — | 1 | 4.48 |
| CHEMBL4859457 | — | — | 1 | 4.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL374508 | E-64 | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4877896 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4845877 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL4859457 | — | IC50 | = | 34000.0 | nM | 4.47 |