Assay Detail
Binding
CHEMBL4812908
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant Trypanosoma brucei rhodesain using Z-FR-AMC as substrate by fluorimetric analysis relative to control
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma brucei |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Computer-aided design of 1,4-naphthoquinone-based inhibitors targeting cruzain and rhodesain cysteine proteases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.41 | 4.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4845877 | — | — | 1 | 4.54 |
| CHEMBL4877896 | — | — | 1 | 4.52 |
| CHEMBL4859457 | — | — | 1 | 4.18 |
| CHEMBL240963 | LAWSONE | — | 1 | - |
| CHEMBL15193 | LAPACHOL | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4845877 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL4877896 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4859457 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL240963 | LAWSONE | IC50 | > | 100000.0 | nM | - |
| CHEMBL15193 | LAPACHOL | IC50 | > | 100000.0 | nM | - |