Assay Detail
Binding
CHEMBL4813050
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Agonist activity at Gal4-fused human PPARalpha co-expressed with RXRalpha in monkey CV1 cells assessed as PPRE transcriptional activation incubated for 45 hrs by luciferase reporter gene assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of novel modulators for the PPARα (peroxisome proliferator activated receptor α): Potential therapies for nonalcoholic fatty liver disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 8.80 | 9.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4866115 | — | — | 1 | 9.07 |
| CHEMBL4861761 | — | — | 1 | 9.06 |
| CHEMBL4879102 | — | — | 1 | 9.02 |
| CHEMBL4855604 | — | — | 1 | 9.00 |
| CHEMBL4847453 | — | — | 1 | 9.00 |
| CHEMBL4877444 | — | — | 1 | 8.82 |
| CHEMBL4870407 | — | — | 1 | 8.52 |
| CHEMBL4847989 | — | — | 1 | 7.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4866115 | — | EC50 | = | 0.85 | nM | 9.07 |
| CHEMBL4861761 | — | EC50 | = | 0.87 | nM | 9.06 |
| CHEMBL4879102 | — | EC50 | = | 0.95 | nM | 9.02 |
| CHEMBL4855604 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4847453 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4877444 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4870407 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4847989 | — | EC50 | = | 12.0 | nM | 7.92 |