Assay Detail
Binding
CHEMBL4813167
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Nav1.6 expressed in HEK293 cells by sodium influx assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium channel protein type 8 subunit alpha (CHEMBL5202) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of aryl sulfonamides as novel and potent inhibitors of Na<sub>V</sub>1.5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.96 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4854735 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4854735 | — | IC50 | = | 110.0 | nM | 6.96 |