Assay Detail
Binding
CHEMBL4813299
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Inhibition of HIV-1 reverse transcriptase assessed as inhibition of biotin-dUTP incorporation into cDNA measured after 1 hr by ELISA
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Exploiting the hydrophobic channel of the NNIBP: Discovery of novel diarylpyrimidines as HIV-1 NNRTIs against wild-type and K103N mutant viruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.42 | 7.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 7.32 |
| CHEMBL4870132 | — | — | 1 | 6.89 |
| CHEMBL4857180 | — | — | 1 | 6.64 |
| CHEMBL4865294 | — | — | 1 | 5.70 |
| CHEMBL4875791 | — | — | 1 | 5.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308954 | ETRAVIRINE | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL4870132 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4857180 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4865294 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL4875791 | — | IC50 | = | 2980.0 | nM | 5.53 |