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Assay Detail

CHEMBL4813306

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of HDAC6 (unknown origin)
28
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Histone deacetylase 6 (CHEMBL1865)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of macrocyclic HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation.
Yu W, Fells J, Clausen D, Liu J, Klein DJ, Christine Chung C, Myers RW, Wu J, Wu G, Howell BJ, Barnard RJO, Kozlowski J.
Bioorg Med Chem Lett (2021) 47 : 128168 -128168
PubMed 34091041 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 28 5.43 6.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4878197 1 6.66
CHEMBL2448576 1 6.17
CHEMBL4863325 1 6.07
CHEMBL4856631 1 5.70
CHEMBL4859998 1 5.53
CHEMBL4849920 2 5.27
CHEMBL4848392 2 5.26
CHEMBL4869027 1 5.24
CHEMBL4859950 1 5.11
CHEMBL4847876 2 5.01
CHEMBL4776685 1 5.01
CHEMBL4785376 1 4.76
CHEMBL4852075 1 -
CHEMBL4876853 1 -
CHEMBL4855445 1 -
CHEMBL4854377 1 -
CHEMBL4866612 1 -
CHEMBL4862470 1 -
CHEMBL4853593 1 -
CHEMBL4849063 1 -
CHEMBL4876610 1 -
CHEMBL4860990 1 -
CHEMBL4869000 1 -
CHEMBL4860000 1 -
CHEMBL443392 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4878197 IC50 = 218.0 nM 6.66
CHEMBL2448576 IC50 = 680.0 nM 6.17
CHEMBL4863325 IC50 = 858.0 nM 6.07
CHEMBL4856631 IC50 = 2000.0 nM 5.70
CHEMBL4859998 IC50 = 2977.0 nM 5.53
CHEMBL4849920 IC50 = 5394.0 nM 5.27
CHEMBL4848392 IC50 = 5549.0 nM 5.26
CHEMBL4869027 IC50 = 5749.0 nM 5.24
CHEMBL4859950 IC50 = 7847.0 nM 5.11
CHEMBL4847876 IC50 = 9829.0 nM 5.01
CHEMBL4776685 IC50 = 9829.0 nM 5.01
CHEMBL4785376 IC50 = 17460.0 nM 4.76
CHEMBL4847876 IC50 = 17460.0 nM 4.76
CHEMBL4849063 IC50 > 900.0 nM -
CHEMBL4849920 IC50 - -
CHEMBL4860000 IC50 > 900.0 nM -
CHEMBL4869000 IC50 > 900.0 nM -
CHEMBL4860990 IC50 > 900.0 nM -
CHEMBL4876610 IC50 > 900.0 nM -
CHEMBL4848392 IC50 - -
CHEMBL4853593 IC50 > 900.0 nM -
CHEMBL4852075 IC50 > 900.0 nM -
CHEMBL4876853 IC50 > 900.0 nM -
CHEMBL4862470 IC50 > 900.0 nM -
CHEMBL4866612 IC50 > 900.0 nM -
CHEMBL4854377 IC50 > 900.0 nM -
CHEMBL443392 IC50 > 900.0 nM -
CHEMBL4855445 IC50 > 900.0 nM -