Assay Detail
Functional
CHEMBL4813352
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Cytotoxicity in human HMEC cells assessed as inhibition of cell proliferation measured by CCK-8 assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HMEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The ester derivatives obtained by C-ring modification of podophyllotoxin induce apoptosis and inhibited proliferation in PC-3M cells via down-regulation of PI3K/Akt signaling pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.75 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4852756 | — | — | 1 | 7.10 |
| CHEMBL4857960 | — | — | 1 | 6.93 |
| CHEMBL4859712 | — | — | 1 | 6.37 |
| CHEMBL4867624 | — | — | 1 | 6.17 |
| CHEMBL4174065 | — | — | 1 | 6.12 |
| CHEMBL4858684 | — | — | 1 | 6.03 |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 5.87 |
| CHEMBL4854505 | — | — | 1 | 5.75 |
| CHEMBL4852095 | — | — | 1 | 5.75 |
| CHEMBL4176475 | — | — | 1 | 5.63 |
| CHEMBL4167643 | — | — | 1 | 5.61 |
| CHEMBL4870295 | — | — | 1 | 5.61 |
| CHEMBL4874885 | — | — | 1 | 5.58 |
| CHEMBL4852086 | — | — | 1 | 5.56 |
| CHEMBL4863643 | — | — | 1 | 5.51 |
| CHEMBL4168614 | — | — | 1 | 5.49 |
| CHEMBL2262705 | 4-O-PODOPHYLLOTOXINYL-ISONICOTINATE | — | 1 | 5.43 |
| CHEMBL4171971 | — | — | 1 | 5.35 |
| CHEMBL4849412 | — | — | 1 | 5.27 |
| CHEMBL4175511 | — | — | 1 | 5.08 |
| CHEMBL4166147 | — | — | 1 | 4.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4852756 | — | IC50 | = | 79.46 | nM | 7.10 |
| CHEMBL4857960 | — | IC50 | = | 116.1 | nM | 6.93 |
| CHEMBL4859712 | — | IC50 | = | 423.8 | nM | 6.37 |
| CHEMBL4867624 | — | IC50 | = | 672.5 | nM | 6.17 |
| CHEMBL4174065 | — | IC50 | = | 768.1 | nM | 6.12 |
| CHEMBL4858684 | — | IC50 | = | 936.2 | nM | 6.03 |
| CHEMBL61 | PODOFILOX | IC50 | = | 1338.0 | nM | 5.87 |
| CHEMBL4854505 | — | IC50 | = | 1796.0 | nM | 5.75 |
| CHEMBL4852095 | — | IC50 | = | 1772.0 | nM | 5.75 |
| CHEMBL4176475 | — | IC50 | = | 2365.0 | nM | 5.63 |
| CHEMBL4167643 | — | IC50 | = | 2462.0 | nM | 5.61 |
| CHEMBL4870295 | — | IC50 | = | 2436.0 | nM | 5.61 |
| CHEMBL4874885 | — | IC50 | = | 2601.0 | nM | 5.58 |
| CHEMBL4852086 | — | IC50 | = | 2752.0 | nM | 5.56 |
| CHEMBL4863643 | — | IC50 | = | 3070.0 | nM | 5.51 |
| CHEMBL4168614 | — | IC50 | = | 3230.0 | nM | 5.49 |
| CHEMBL2262705 | 4-O-PODOPHYLLOTOXINYL-ISONICOTINATE | IC50 | = | 3722.0 | nM | 5.43 |
| CHEMBL4171971 | — | IC50 | = | 4479.0 | nM | 5.35 |
| CHEMBL4849412 | — | IC50 | = | 5380.0 | nM | 5.27 |
| CHEMBL4175511 | — | IC50 | = | 8419.0 | nM | 5.08 |
| CHEMBL4166147 | — | IC50 | = | 27780.0 | nM | 4.56 |