Assay Detail
Functional
CHEMBL4813353
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Cytotoxicity in human A549 cells assessed as inhibition of cell proliferation measured by CCK-8 assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The ester derivatives obtained by C-ring modification of podophyllotoxin induce apoptosis and inhibited proliferation in PC-3M cells via down-regulation of PI3K/Akt signaling pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.56 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 8.27 |
| CHEMBL4174065 | — | — | 1 | 8.02 |
| CHEMBL2262705 | 4-O-PODOPHYLLOTOXINYL-ISONICOTINATE | — | 1 | 7.79 |
| CHEMBL4167643 | — | — | 1 | 7.63 |
| CHEMBL4175511 | — | — | 1 | 7.55 |
| CHEMBL4852756 | — | — | 1 | 7.40 |
| CHEMBL4166147 | — | — | 1 | 7.37 |
| CHEMBL4867624 | — | — | 1 | 7.17 |
| CHEMBL4859712 | — | — | 1 | 6.84 |
| CHEMBL4857960 | — | — | 1 | 6.81 |
| CHEMBL4854505 | — | — | 1 | 6.50 |
| CHEMBL4852095 | — | — | 1 | 6.30 |
| CHEMBL4858684 | — | — | 1 | 6.27 |
| CHEMBL4168614 | — | — | 1 | 6.22 |
| CHEMBL4874885 | — | — | 1 | 5.99 |
| CHEMBL4852086 | — | — | 1 | 5.97 |
| CHEMBL4849412 | — | — | 1 | 5.34 |
| CHEMBL4176475 | — | — | 1 | 5.19 |
| CHEMBL4863643 | — | — | 1 | 5.13 |
| CHEMBL4171971 | — | — | 1 | 5.10 |
| CHEMBL4870295 | — | — | 1 | 4.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | IC50 | = | 5.37 | nM | 8.27 |
| CHEMBL4174065 | — | IC50 | = | 9.54 | nM | 8.02 |
| CHEMBL2262705 | 4-O-PODOPHYLLOTOXINYL-ISONICOTINATE | IC50 | = | 16.34 | nM | 7.79 |
| CHEMBL4167643 | — | IC50 | = | 23.41 | nM | 7.63 |
| CHEMBL4175511 | — | IC50 | = | 28.35 | nM | 7.55 |
| CHEMBL4852756 | — | IC50 | = | 40.18 | nM | 7.40 |
| CHEMBL4166147 | — | IC50 | = | 43.05 | nM | 7.37 |
| CHEMBL4867624 | — | IC50 | = | 68.43 | nM | 7.17 |
| CHEMBL4859712 | — | IC50 | = | 143.1 | nM | 6.84 |
| CHEMBL4857960 | — | IC50 | = | 154.8 | nM | 6.81 |
| CHEMBL4854505 | — | IC50 | = | 314.5 | nM | 6.50 |
| CHEMBL4852095 | — | IC50 | = | 503.7 | nM | 6.30 |
| CHEMBL4858684 | — | IC50 | = | 538.8 | nM | 6.27 |
| CHEMBL4168614 | — | IC50 | = | 600.4 | nM | 6.22 |
| CHEMBL4874885 | — | IC50 | = | 1032.0 | nM | 5.99 |
| CHEMBL4852086 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL4849412 | — | IC50 | = | 4592.0 | nM | 5.34 |
| CHEMBL4176475 | — | IC50 | = | 6436.0 | nM | 5.19 |
| CHEMBL4863643 | — | IC50 | = | 7325.0 | nM | 5.13 |
| CHEMBL4171971 | — | IC50 | = | 7961.0 | nM | 5.10 |
| CHEMBL4870295 | — | IC50 | = | 11232.0 | nM | 4.95 |