Assay Detail
Functional
CHEMBL4813355
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Cytotoxicity in human HepG2 cells assessed as inhibition of cell proliferation measured by CCK-8 assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The ester derivatives obtained by C-ring modification of podophyllotoxin induce apoptosis and inhibited proliferation in PC-3M cells via down-regulation of PI3K/Akt signaling pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 4.57 | 6.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4171971 | — | — | 1 | 6.06 |
| CHEMBL4859712 | — | — | 1 | 5.63 |
| CHEMBL4870295 | — | — | 1 | 4.96 |
| CHEMBL4867624 | — | — | 1 | 4.57 |
| CHEMBL4852095 | — | — | 1 | 4.47 |
| CHEMBL4874885 | — | — | 1 | 4.29 |
| CHEMBL4168614 | — | — | 1 | 4.29 |
| CHEMBL4174065 | — | — | 1 | 4.29 |
| CHEMBL4858684 | — | — | 1 | 4.28 |
| CHEMBL4176475 | — | — | 1 | 4.22 |
| CHEMBL4166147 | — | — | 1 | 4.22 |
| CHEMBL4175511 | — | — | 1 | 4.07 |
| CHEMBL4852086 | — | — | 1 | 4.05 |
| CHEMBL4854505 | — | — | 1 | - |
| CHEMBL4167643 | — | — | 1 | - |
| CHEMBL4857960 | — | — | 1 | - |
| CHEMBL2262705 | 4-O-PODOPHYLLOTOXINYL-ISONICOTINATE | — | 1 | - |
| CHEMBL4863643 | — | — | 1 | - |
| CHEMBL4852756 | — | — | 1 | - |
| CHEMBL4849412 | — | — | 1 | - |
| CHEMBL61 | PODOFILOX | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4171971 | — | IC50 | = | 865.6 | nM | 6.06 |
| CHEMBL4859712 | — | IC50 | = | 2341.0 | nM | 5.63 |
| CHEMBL4870295 | — | IC50 | = | 10905.0 | nM | 4.96 |
| CHEMBL4867624 | — | IC50 | = | 26887.0 | nM | 4.57 |
| CHEMBL4852095 | — | IC50 | = | 33908.0 | nM | 4.47 |
| CHEMBL4874885 | — | IC50 | = | 51042.0 | nM | 4.29 |
| CHEMBL4168614 | — | IC50 | = | 50794.0 | nM | 4.29 |
| CHEMBL4174065 | — | IC50 | = | 50739.0 | nM | 4.29 |
| CHEMBL4858684 | — | IC50 | = | 53104.0 | nM | 4.28 |
| CHEMBL4176475 | — | IC50 | = | 60295.0 | nM | 4.22 |
| CHEMBL4166147 | — | IC50 | = | 60063.0 | nM | 4.22 |
| CHEMBL4175511 | — | IC50 | = | 84886.0 | nM | 4.07 |
| CHEMBL4852086 | — | IC50 | = | 88714.0 | nM | 4.05 |
| CHEMBL4854505 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4167643 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4857960 | — | IC50 | = | 149077.0 | nM | - |
| CHEMBL2262705 | 4-O-PODOPHYLLOTOXINYL-ISONICOTINATE | IC50 | = | 187707.0 | nM | - |
| CHEMBL4863643 | — | IC50 | = | 141102.0 | nM | - |
| CHEMBL4852756 | — | IC50 | = | 108633.0 | nM | - |
| CHEMBL4849412 | — | IC50 | = | 117290.0 | nM | - |
| CHEMBL61 | PODOFILOX | IC50 | > | 200000.0 | nM | - |