Assay Detail
Functional
CHEMBL4813384
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Antiproliferative activity against human A549 cells assessed as inhibition of proliferation after 72 hrs by SRB assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antiproliferative screening of novel doubly modified colchicines containing urea, thiourea and guanidine moieties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.40 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4871687 | — | — | 1 | 8.70 |
| CHEMBL4865714 | — | — | 1 | 8.40 |
| CHEMBL4846154 | — | — | 1 | 8.31 |
| CHEMBL88059 | — | — | 1 | 7.92 |
| CHEMBL4851819 | — | — | 1 | 7.92 |
| CHEMBL4849061 | — | — | 1 | 7.92 |
| CHEMBL4849665 | — | — | 1 | 7.92 |
| CHEMBL4855629 | — | — | 1 | 7.89 |
| CHEMBL4853080 | — | — | 1 | 7.89 |
| CHEMBL4854676 | — | — | 1 | 7.85 |
| CHEMBL4845875 | — | — | 1 | 7.82 |
| CHEMBL4863458 | — | — | 1 | 7.64 |
| CHEMBL4858903 | — | — | 1 | 7.57 |
| CHEMBL4846687 | — | — | 1 | 7.48 |
| CHEMBL4862090 | — | — | 1 | 7.47 |
| CHEMBL4848059 | — | — | 1 | 7.42 |
| CHEMBL4846321 | — | — | 1 | 7.16 |
| CHEMBL4864484 | — | — | 1 | 7.13 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.12 |
| CHEMBL4874312 | — | — | 1 | 7.11 |
| CHEMBL4873070 | — | — | 1 | 7.10 |
| CHEMBL4872420 | — | — | 1 | 7.09 |
| CHEMBL4863315 | — | — | 1 | 7.07 |
| CHEMBL4859217 | — | — | 1 | 6.96 |
| CHEMBL4875384 | — | — | 1 | 6.72 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.72 |
| CHEMBL4878150 | — | — | 1 | 6.13 |
| CHEMBL4866152 | — | — | 1 | 6.07 |
| CHEMBL4859299 | — | — | 1 | 6.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4871687 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4865714 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4846154 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL88059 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4851819 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4849061 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4849665 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4855629 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4853080 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4854676 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4845875 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4863458 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4858903 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4846687 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4862090 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4848059 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4846321 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4864484 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL107 | COLCHICINE | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL4874312 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL4873070 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL4872420 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL4863315 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL4859217 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4875384 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4878150 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL4866152 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL4859299 | — | IC50 | = | 930.0 | nM | 6.03 |