Assay Detail
Binding
CHEMBL4813535
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Inhibition of HDAC6 (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of dual mTOR/HDAC6 inhibitors in MDA-MB-231 cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.96 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3655950 | — | — | 1 | 8.77 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 8.70 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 7.82 |
| CHEMBL4873811 | — | — | 1 | 7.25 |
| CHEMBL4066043 | — | — | 1 | 7.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3655950 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2018302 | TUBASTATIN A | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4873811 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL4066043 | — | IC50 | = | 56.0 | nM | 7.25 |