Assay Detail
Binding
CHEMBL4813583
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Inhibition of human cathepsin C
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of potent and selective Cathepsin C inhibitors free of aortic binding liability by application of a conformational restriction strategy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.32 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3261926 | — | — | 1 | 9.00 |
| CHEMBL4865824 | — | — | 1 | 8.34 |
| CHEMBL4869673 | — | — | 1 | 8.19 |
| CHEMBL4856217 | — | — | 1 | 8.03 |
| CHEMBL4875554 | — | — | 1 | 7.99 |
| CHEMBL4850769 | — | — | 1 | 7.83 |
| CHEMBL4864151 | — | — | 1 | 7.55 |
| CHEMBL4869840 | — | — | 1 | 7.36 |
| CHEMBL4851884 | — | — | 1 | 7.11 |
| CHEMBL4854705 | — | — | 1 | 7.11 |
| CHEMBL4570759 | — | — | 1 | 7.04 |
| CHEMBL4876996 | — | — | 1 | 6.81 |
| CHEMBL4848266 | — | — | 1 | 6.65 |
| CHEMBL4849657 | — | — | 1 | 6.64 |
| CHEMBL4846681 | — | — | 1 | 6.51 |
| CHEMBL4847757 | — | — | 1 | 6.41 |
| CHEMBL4860749 | — | — | 1 | 5.90 |
| CHEMBL4877299 | — | — | 1 | - |
| CHEMBL4851188 | — | — | 1 | - |
| CHEMBL4879373 | — | — | 1 | - |
| CHEMBL4869747 | — | — | 1 | - |
| CHEMBL4846254 | — | — | 1 | - |
| CHEMBL4845795 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3261926 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4865824 | — | IC50 | = | 4.62 | nM | 8.34 |
| CHEMBL4869673 | — | IC50 | = | 6.45 | nM | 8.19 |
| CHEMBL4856217 | — | IC50 | = | 9.27 | nM | 8.03 |
| CHEMBL4875554 | — | IC50 | = | 10.17 | nM | 7.99 |
| CHEMBL4850769 | — | IC50 | = | 14.89 | nM | 7.83 |
| CHEMBL4864151 | — | IC50 | = | 27.83 | nM | 7.55 |
| CHEMBL4869840 | — | IC50 | = | 44.01 | nM | 7.36 |
| CHEMBL4851884 | — | IC50 | = | 77.56 | nM | 7.11 |
| CHEMBL4854705 | — | IC50 | = | 77.73 | nM | 7.11 |
| CHEMBL4570759 | — | IC50 | = | 91.51 | nM | 7.04 |
| CHEMBL4876996 | — | IC50 | = | 153.6 | nM | 6.81 |
| CHEMBL4848266 | — | IC50 | = | 222.6 | nM | 6.65 |
| CHEMBL4849657 | — | IC50 | = | 227.9 | nM | 6.64 |
| CHEMBL4846681 | — | IC50 | = | 308.1 | nM | 6.51 |
| CHEMBL4847757 | — | IC50 | = | 394.0 | nM | 6.41 |
| CHEMBL4860749 | — | IC50 | = | 1248.0 | nM | 5.90 |
| CHEMBL4877299 | — | IC50 | - | — | - | |
| CHEMBL4851188 | — | IC50 | - | — | - | |
| CHEMBL4879373 | — | IC50 | - | — | - | |
| CHEMBL4869747 | — | IC50 | - | — | - | |
| CHEMBL4846254 | — | IC50 | - | — | - | |
| CHEMBL4845795 | — | IC50 | - | — | - |