Assay Detail
Binding
CHEMBL4813624
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Binding affinity to Mc1-1 (unknown origin) by fluorescence polarization competition assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 (CHEMBL4361) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and biological evaluation of dual Bcl-2/Mcl-1 inhibitors bearing 2-(1H-indol-4-yl)benzoic acid scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 6.67 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4851522 | — | — | 1 | 9.00 |
| CHEMBL4872671 | — | — | 1 | 7.52 |
| CHEMBL4870458 | — | — | 1 | 7.16 |
| CHEMBL4870837 | — | — | 1 | 6.92 |
| CHEMBL4856143 | — | — | 1 | 6.77 |
| CHEMBL4864929 | — | — | 1 | 6.77 |
| CHEMBL4875429 | — | — | 1 | 6.77 |
| CHEMBL51483 | GOSSYPOL | 3.0 | 1 | 6.75 |
| CHEMBL4876147 | — | — | 1 | 6.72 |
| CHEMBL4860820 | — | — | 1 | 6.66 |
| CHEMBL4846508 | — | — | 1 | 6.64 |
| CHEMBL4876348 | — | — | 1 | 6.60 |
| CHEMBL4855114 | — | — | 1 | 6.57 |
| CHEMBL4872495 | — | — | 1 | 6.57 |
| CHEMBL4878113 | — | — | 1 | 6.55 |
| CHEMBL4852823 | — | — | 1 | 6.54 |
| CHEMBL4868913 | — | — | 1 | 6.44 |
| CHEMBL4872320 | — | — | 1 | 6.35 |
| CHEMBL4859740 | — | — | 1 | 6.15 |
| CHEMBL4870608 | — | — | 1 | 6.04 |
| CHEMBL4865871 | — | — | 1 | 6.02 |
| CHEMBL4860027 | — | — | 1 | 5.92 |
| CHEMBL4864735 | — | — | 1 | 5.88 |
| CHEMBL3137309 | VENETOCLAX | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4851522 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL4872671 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL4870458 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL4870837 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL4856143 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL4864929 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL4875429 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL51483 | GOSSYPOL | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL4876147 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL4860820 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL4846508 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL4876348 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL4855114 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL4872495 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL4878113 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL4852823 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL4868913 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL4872320 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL4859740 | — | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL4870608 | — | Ki | = | 920.0 | nM | 6.04 |
| CHEMBL4865871 | — | Ki | = | 960.0 | nM | 6.02 |
| CHEMBL4860027 | — | Ki | = | 1190.0 | nM | 5.92 |
| CHEMBL4864735 | — | Ki | = | 1330.0 | nM | 5.88 |
| CHEMBL3137309 | VENETOCLAX | Ki | > | 200000.0 | nM | - |