Assay Detail
Binding
CHEMBL4813625
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Binding affinity to Bcl-2 (unknown origin) by fluorescence polarization competition assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Bcl2-associated agonist of cell death (CHEMBL3817) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and biological evaluation of dual Bcl-2/Mcl-1 inhibitors bearing 2-(1H-indol-4-yl)benzoic acid scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 6.06 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4872320 | — | — | 1 | 7.00 |
| CHEMBL4872671 | — | — | 1 | 6.60 |
| CHEMBL4864929 | — | — | 1 | 6.60 |
| CHEMBL4855114 | — | — | 1 | 6.52 |
| CHEMBL4870608 | — | — | 1 | 6.44 |
| CHEMBL51483 | GOSSYPOL | 3.0 | 1 | 6.34 |
| CHEMBL4860820 | — | — | 1 | 6.31 |
| CHEMBL4852823 | — | — | 1 | 6.28 |
| CHEMBL4864735 | — | — | 1 | 6.25 |
| CHEMBL4870458 | — | — | 1 | 6.18 |
| CHEMBL4846508 | — | — | 1 | 6.10 |
| CHEMBL4856143 | — | — | 1 | 6.09 |
| CHEMBL4870837 | — | — | 1 | 6.09 |
| CHEMBL4876348 | — | — | 1 | 6.06 |
| CHEMBL4876147 | — | — | 1 | 5.97 |
| CHEMBL4859740 | — | — | 1 | 5.89 |
| CHEMBL4872495 | — | — | 1 | 5.89 |
| CHEMBL4875429 | — | — | 1 | 5.76 |
| CHEMBL4865871 | — | — | 1 | 5.75 |
| CHEMBL4878113 | — | — | 1 | 5.59 |
| CHEMBL4868913 | — | — | 1 | 5.49 |
| CHEMBL4860027 | — | — | 1 | 5.34 |
| CHEMBL3137309 | VENETOCLAX | 4.0 | 1 | 4.80 |
| CHEMBL4851522 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4872320 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL4872671 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL4864929 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL4855114 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL4870608 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL51483 | GOSSYPOL | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL4860820 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL4852823 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL4864735 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL4870458 | — | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL4846508 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL4856143 | — | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL4870837 | — | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL4876348 | — | Ki | = | 870.0 | nM | 6.06 |
| CHEMBL4876147 | — | Ki | = | 1080.0 | nM | 5.97 |
| CHEMBL4859740 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL4872495 | — | Ki | = | 1280.0 | nM | 5.89 |
| CHEMBL4875429 | — | Ki | = | 1740.0 | nM | 5.76 |
| CHEMBL4865871 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL4878113 | — | Ki | = | 2550.0 | nM | 5.59 |
| CHEMBL4868913 | — | Ki | = | 3210.0 | nM | 5.49 |
| CHEMBL4860027 | — | Ki | = | 4530.0 | nM | 5.34 |
| CHEMBL3137309 | VENETOCLAX | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL4851522 | — | Ki | - | — | - |