Assay Detail
Binding
CHEMBL4813813
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by protein dilution in acetate buffer and further incubated for 96 hrs at pH 4.6 by thioflavin-T fluorescence assay
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitory activities of anthraquinone and xanthone derivatives against transthyretin amyloidogenesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 4.89 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2103837 | TAFAMIDIS | 4.0 | 1 | 5.28 |
| CHEMBL41286 | DIACEREIN | 3.0 | 1 | 5.27 |
| CHEMBL4850762 | — | — | 1 | 5.19 |
| CHEMBL898 | DIFLUNISAL | 4.0 | 1 | 5.18 |
| CHEMBL4851268 | — | — | 1 | 5.17 |
| CHEMBL4866842 | — | — | 1 | 5.11 |
| CHEMBL4855105 | — | — | 1 | 5.04 |
| CHEMBL260553 | — | — | 1 | 5.00 |
| CHEMBL4859052 | — | — | 1 | 5.00 |
| CHEMBL4857993 | — | — | 1 | 5.00 |
| CHEMBL4860573 | — | — | 1 | 5.00 |
| CHEMBL4870376 | — | — | 1 | 4.96 |
| CHEMBL4874413 | — | — | 1 | 4.92 |
| CHEMBL4849950 | — | — | 1 | 4.92 |
| CHEMBL418068 | RHEIN | — | 1 | 4.92 |
| CHEMBL294264 | PURPURIN | — | 1 | 4.92 |
| CHEMBL4864788 | — | — | 1 | 4.92 |
| CHEMBL4864022 | — | — | 1 | 4.89 |
| CHEMBL4875739 | — | — | 1 | 4.89 |
| CHEMBL4868175 | — | — | 1 | 4.89 |
| CHEMBL4866802 | — | — | 1 | 4.89 |
| CHEMBL4861683 | — | — | 1 | 4.72 |
| CHEMBL4876565 | — | — | 1 | 4.68 |
| CHEMBL4847759 | — | — | 1 | 4.66 |
| CHEMBL23760 | — | — | 1 | 4.66 |
| CHEMBL4872197 | — | — | 1 | 4.62 |
| CHEMBL455581 | — | — | 1 | 4.55 |
| CHEMBL4850646 | — | — | 1 | 4.35 |
| CHEMBL3884338 | — | — | 1 | 4.30 |
| CHEMBL178 | DAUNORUBICIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2103837 | TAFAMIDIS | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL41286 | DIACEREIN | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL4850762 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL898 | DIFLUNISAL | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL4851268 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4866842 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4855105 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL260553 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4859052 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4857993 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4860573 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4870376 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4864788 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4849950 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4874413 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL418068 | RHEIN | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL294264 | PURPURIN | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4864022 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4875739 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4868175 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4866802 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4861683 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL4876565 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL23760 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL4847759 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL4872197 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL455581 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL4850646 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL3884338 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL55761 | ANTHRARUFIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL1722314 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4863120 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4860862 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL53418 | DANTHRON | IC50 | > | 100000.0 | nM | - |
| CHEMBL41092 | CHRYSOPHANOL | IC50 | > | 100000.0 | nM | - |
| CHEMBL4876687 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL289277 | EMODIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL42624 | PHYSCION | IC50 | > | 100000.0 | nM | - |
| CHEMBL40275 | ALOE-EMODIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL55814 | ATHRAQUINONES A | IC50 | > | 100000.0 | nM | - |
| CHEMBL29898 | QUINALIZARIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL4872865 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL17594 | QUINIZARIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL4853146 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL178 | DAUNORUBICIN | IC50 | > | 100000.0 | nM | - |