Assay Detail
Binding
CHEMBL4814440
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human LSD1 (172 to 852 residues) using Bio-H3K4me2 (1 to 24 residues) as substrate incubated for 1 hr by TR-FRET assay
7
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Lysine-specific histone demethylase 1A (CHEMBL6136) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Tranylcypromine Based Lysine-Specific Demethylase 1 Inhibitor: Summary and Perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.45 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4855475 | — | — | 1 | 8.96 |
| CHEMBL4861378 | — | — | 1 | 8.66 |
| CHEMBL4851339 | — | — | 1 | 8.52 |
| CHEMBL4872682 | — | — | 1 | 8.02 |
| CHEMBL4856722 | — | — | 2 | 6.77 |
| CHEMBL4857247 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4855475 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4861378 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4851339 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4872682 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL4856722 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4856722 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4857247 | — | IC50 | = | 8300.0 | nM | 5.08 |