Assay Detail
Binding
CHEMBL4814515
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LsrK expressed in Escherichia coli JW5503 harboring plasmid pET-Plsrlux assessed as reduction in autoinducer2-mediated quorum sensing activation by luminescence method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Tackling Antimicrobial Resistance with Small Molecules Targeting LsrK: Challenges and Opportunities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.68 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4854381 | — | — | 1 | 6.40 |
| CHEMBL3898662 | — | — | 1 | 6.22 |
| CHEMBL4872256 | — | — | 1 | 6.00 |
| CHEMBL4878358 | — | — | 1 | 5.70 |
| CHEMBL4855369 | — | — | 1 | 5.00 |
| CHEMBL4877532 | — | — | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4854381 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3898662 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4872256 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4878358 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4855369 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4877532 | — | IC50 | = | 17000.0 | nM | 4.77 |