Assay Detail
Binding
CHEMBL4814516
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Salmonella typhimurium LsrK expressed in Escherichia coli MET1158 incubated for 30 mins followed by DPD and ATP addition and measured after 15 mins by kinase-glo max luminescent assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Tackling Antimicrobial Resistance with Small Molecules Targeting LsrK: Challenges and Opportunities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.46 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL210868 | AURIN | — | 1 | 6.00 |
| CHEMBL275938 | AURINTRICARBOXYLIC ACID | — | 1 | 6.00 |
| CHEMBL173530 | STICTIC ACID | — | 1 | 5.52 |
| CHEMBL301982 | CELASTROL | — | 1 | 5.40 |
| CHEMBL4866141 | — | — | 1 | 5.16 |
| CHEMBL4858369 | — | — | 1 | 5.16 |
| CHEMBL4868769 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL210868 | AURIN | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL275938 | AURINTRICARBOXYLIC ACID | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL173530 | STICTIC ACID | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL301982 | CELASTROL | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4866141 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4858369 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4868769 | — | IC50 | = | 10000.0 | nM | 5.00 |