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Assay Detail

CHEMBL4814524

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Binding
Antagonist activity at TLR7 (unknown origin)
ChEMBL ↗
55
Total Activities
55
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Toll-like receptor 7 (CHEMBL5936) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and characterization of new potent TLR7 antagonists based on analysis of the binding mode using biomolecular simulations.
Pal S, Paul B, Bandopadhyay P, Preethy N, Sarkar D, Rahaman O, Goon S, Roy S, Ganguly D, Talukdar A.
Eur J Med Chem (2021) 210 : 112978 -112978
PubMed 33189437 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 55 5.31 6.37

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4853223 — — 1 6.37
CHEMBL4878190 — — 1 6.34
CHEMBL4855190 — — 1 6.30
CHEMBL4281194 — — 1 6.16
CHEMBL1535 HYDROXYCHLOROQUINE 4.0 1 6.10
CHEMBL4868741 — — 1 6.10
CHEMBL4868248 — — 1 6.01
CHEMBL4853422 — — 1 6.00
CHEMBL4100834 — — 1 5.94
CHEMBL4282131 — — 1 5.92
CHEMBL4278635 — — 1 5.92
CHEMBL4280997 — — 1 5.89
CHEMBL4290193 — — 1 5.85
CHEMBL4870581 — — 1 5.85
CHEMBL4276673 — — 1 5.85
CHEMBL4065452 — — 1 5.81
CHEMBL4866497 — — 1 5.38
CHEMBL4291815 — — 1 5.36
CHEMBL4082132 — — 1 5.34
CHEMBL4287813 — — 1 5.34
CHEMBL4100657 — — 1 5.33
CHEMBL4284496 — — 1 5.31
CHEMBL4067391 — — 1 5.30
CHEMBL4283550 — — 1 5.27
CHEMBL4279467 — — 1 5.25
CHEMBL4284607 — — 1 5.24
CHEMBL4290016 — — 1 5.24
CHEMBL4088644 — — 1 5.12
CHEMBL4871451 — — 1 5.09
CHEMBL4073879 — — 1 5.08

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4853223 — IC50 = 430.0 nM 6.37
CHEMBL4878190 — IC50 = 460.0 nM 6.34
CHEMBL4855190 — IC50 = 500.0 nM 6.30
CHEMBL4281194 — IC50 = 700.0 nM 6.16
CHEMBL1535 HYDROXYCHLOROQUINE IC50 = 800.0 nM 6.10
CHEMBL4868741 — IC50 = 800.0 nM 6.10
CHEMBL4868248 — IC50 = 980.0 nM 6.01
CHEMBL4853422 — IC50 = 990.0 nM 6.00
CHEMBL4100834 — IC50 = 1140.0 nM 5.94
CHEMBL4282131 — IC50 = 1200.0 nM 5.92
CHEMBL4278635 — IC50 = 1200.0 nM 5.92
CHEMBL4280997 — IC50 = 1300.0 nM 5.89
CHEMBL4276673 — IC50 = 1400.0 nM 5.85
CHEMBL4870581 — IC50 = 1400.0 nM 5.85
CHEMBL4290193 — IC50 = 1400.0 nM 5.85
CHEMBL4065452 — IC50 = 1550.0 nM 5.81
CHEMBL4866497 — IC50 = 4200.0 nM 5.38
CHEMBL4291815 — IC50 = 4400.0 nM 5.36
CHEMBL4082132 — IC50 = 4570.0 nM 5.34
CHEMBL4287813 — IC50 = 4600.0 nM 5.34
CHEMBL4100657 — IC50 = 4710.0 nM 5.33
CHEMBL4284496 — IC50 = 4900.0 nM 5.31
CHEMBL4067391 — IC50 = 4990.0 nM 5.30
CHEMBL4283550 — IC50 = 5400.0 nM 5.27
CHEMBL4279467 — IC50 = 5600.0 nM 5.25
CHEMBL4284607 — IC50 = 5800.0 nM 5.24
CHEMBL4290016 — IC50 = 5700.0 nM 5.24
CHEMBL4088644 — IC50 = 7550.0 nM 5.12
CHEMBL4871451 — IC50 = 8090.0 nM 5.09
CHEMBL4073879 — IC50 = 8300.0 nM 5.08
CHEMBL4290314 — IC50 = 8700.0 nM 5.06
CHEMBL4287984 — IC50 = 9600.0 nM 5.02
CHEMBL4279130 — IC50 = 10000.0 nM 5.00
CHEMBL4288225 — IC50 = 10000.0 nM 5.00
CHEMBL4291391 — IC50 = 11000.0 nM 4.96
CHEMBL4290144 — IC50 = 11000.0 nM 4.96
CHEMBL4278682 — IC50 = 16000.0 nM 4.80
CHEMBL4286933 — IC50 = 17000.0 nM 4.77
CHEMBL4291639 — IC50 = 17000.0 nM 4.77
CHEMBL4285558 — IC50 = 17000.0 nM 4.77
CHEMBL4277578 — IC50 = 20700.0 nM 4.68
CHEMBL4284406 — IC50 = 22000.0 nM 4.66
CHEMBL1581298 — IC50 = 23000.0 nM 4.64
CHEMBL4295057 — IC50 = 31000.0 nM 4.51
CHEMBL4868404 — IC50 = 37000.0 nM 4.43
CHEMBL4287549 — IC50 = 53000.0 nM 4.28
CHEMBL4282327 — IC50 = 52000.0 nM 4.28
CHEMBL4874693 — IC50 = 66170.0 nM 4.18
CHEMBL4851769 — IC50 = 272000.0 nM -
CHEMBL95897 — IC50 = 684000.0 nM -