Assay Detail
Binding
CHEMBL4814587
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to GST tagged mouse MKK4 expressed in Escherichia coli expression system measured by Kinomescan assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity mitogen-activated protein kinase kinase 4 (CHEMBL2201) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
From off-to on-target: New BRAF-inhibitor-template-derived compounds selectively targeting mitogen activated protein kinase kinase 4 (MKK4).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 8.65 | 9.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4848804 | — | — | 1 | 9.07 |
| CHEMBL4857316 | — | — | 1 | 8.96 |
| CHEMBL4868537 | — | — | 1 | 8.46 |
| CHEMBL1229517 | VEMURAFENIB | 4.0 | 1 | 8.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4848804 | — | Kd | = | 0.85 | nM | 9.07 |
| CHEMBL4857316 | — | Kd | = | 1.1 | nM | 8.96 |
| CHEMBL4868537 | — | Kd | = | 3.5 | nM | 8.46 |
| CHEMBL1229517 | VEMURAFENIB | Kd | = | 8.2 | nM | 8.09 |