Assay Detail
Functional
CHEMBL4815488
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human histamine D2L receptor receptor expressed in HEK293T cells co-expressing ELucC by beta arrestin2 recruitment assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pharmacological characterization of a new series of carbamoylguanidines reveals potent agonism at the H<sub>2</sub>R and D<sub>3</sub>R.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 5.94 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL240773 | QUINPIROLE | 2.0 | 1 | 7.55 |
| CHEMBL4856059 | — | — | 1 | 6.47 |
| CHEMBL4875600 | — | — | 1 | 6.23 |
| CHEMBL4860528 | — | — | 1 | 5.98 |
| CHEMBL4846380 | — | — | 1 | 5.97 |
| CHEMBL4853107 | — | — | 1 | 5.96 |
| CHEMBL4848815 | — | — | 1 | 5.95 |
| CHEMBL4853772 | — | — | 1 | 5.82 |
| CHEMBL4856005 | — | — | 1 | 5.78 |
| CHEMBL4857560 | — | — | 1 | 5.77 |
| CHEMBL4853668 | — | — | 1 | 5.76 |
| CHEMBL4867962 | — | — | 1 | 5.57 |
| CHEMBL4846201 | — | — | 1 | 5.53 |
| CHEMBL4846638 | — | — | 1 | 5.49 |
| CHEMBL4865765 | — | — | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL240773 | QUINPIROLE | EC50 | = | 28.18 | nM | 7.55 |
| CHEMBL4856059 | — | EC50 | = | 338.84 | nM | 6.47 |
| CHEMBL4875600 | — | EC50 | = | 588.84 | nM | 6.23 |
| CHEMBL4860528 | — | EC50 | = | 1047.13 | nM | 5.98 |
| CHEMBL4846380 | — | EC50 | = | 1071.52 | nM | 5.97 |
| CHEMBL4853107 | — | EC50 | = | 1096.48 | nM | 5.96 |
| CHEMBL4848815 | — | EC50 | = | 1122.02 | nM | 5.95 |
| CHEMBL4853772 | — | EC50 | = | 1513.56 | nM | 5.82 |
| CHEMBL4856005 | — | EC50 | = | 1659.59 | nM | 5.78 |
| CHEMBL4857560 | — | EC50 | = | 1698.24 | nM | 5.77 |
| CHEMBL4853668 | — | EC50 | = | 1737.8 | nM | 5.76 |
| CHEMBL4867962 | — | EC50 | = | 2691.53 | nM | 5.57 |
| CHEMBL4846201 | — | EC50 | = | 2951.21 | nM | 5.53 |
| CHEMBL4846638 | — | EC50 | = | 3235.94 | nM | 5.49 |
| CHEMBL4865765 | — | EC50 | = | 5370.32 | nM | 5.27 |