Assay Detail
Binding
CHEMBL4815493
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of spike glycoprotein S in SARS-CoV-2 pseudovirus infected in human 293T/ACE2 cells assessed as inhibition of viral infection pretreated the virus for 30 mins followed by viral infection measured after 48 hrs by by luciferase reporter gene assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | 293T/ACE2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Spike glycoprotein (CHEMBL4662936) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Axial Chiral Binaphthoquinone and Perylenequinones from the Stromata of <i>Hypocrella bambusae</i> Are SARS-CoV-2 Entry Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.98 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL330348 | HYPOCRELLIN A | — | 1 | 7.42 |
| CHEMBL4869623 | — | — | 1 | 6.92 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.80 |
| CHEMBL4861894 | — | — | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL330348 | HYPOCRELLIN A | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4869623 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4861894 | — | IC50 | = | 170.0 | nM | 6.77 |