Assay Detail
Binding
CHEMBL4815729
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant RIPK2 (unknown origin) using RS repeat peptide as substrate preincubated for 5 mins followed by substrate and ATP addition and further incubated for 2 hrs by ADP-Glo reagent based assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-interacting serine/threonine-protein kinase 2 (CHEMBL5014) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design of pyrido[2,3-d]pyrimidin-7-one inhibitors of receptor interacting protein kinase-2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 7.48 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4847211 | — | — | 1 | 8.30 |
| CHEMBL4864600 | — | — | 1 | 8.22 |
| CHEMBL4861488 | — | — | 1 | 8.10 |
| CHEMBL136244 | — | — | 1 | 7.98 |
| CHEMBL4861447 | — | — | 1 | 7.96 |
| CHEMBL49120 | PD-0166285 | 1.0 | 1 | 7.89 |
| CHEMBL4852860 | — | — | 1 | 7.89 |
| CHEMBL4868894 | — | — | 1 | 7.85 |
| CHEMBL4864714 | — | — | 1 | 7.84 |
| CHEMBL4875011 | — | — | 1 | 7.82 |
| CHEMBL4849134 | — | — | 1 | 7.80 |
| CHEMBL4867467 | — | — | 1 | 7.80 |
| CHEMBL4853179 | — | — | 1 | 7.77 |
| CHEMBL4867716 | — | — | 1 | 7.77 |
| CHEMBL4858463 | — | — | 1 | 7.68 |
| CHEMBL4874031 | — | — | 1 | 7.68 |
| CHEMBL4852513 | — | — | 1 | 7.68 |
| CHEMBL4853711 | — | — | 1 | 7.66 |
| CHEMBL4864576 | — | — | 1 | 7.60 |
| CHEMBL4870434 | — | — | 1 | 7.60 |
| CHEMBL4859351 | — | — | 1 | 7.57 |
| CHEMBL4847571 | — | — | 1 | 7.47 |
| CHEMBL4856366 | — | — | 1 | 7.19 |
| CHEMBL4854929 | — | — | 1 | 6.98 |
| CHEMBL4859716 | — | — | 1 | 6.89 |
| CHEMBL4871544 | — | — | 1 | 4.52 |
| CHEMBL136106 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4847211 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4864600 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4861488 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL136244 | — | IC50 | = | 10.5 | nM | 7.98 |
| CHEMBL4861447 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL49120 | PD-0166285 | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4852860 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4868894 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4864714 | — | IC50 | = | 14.6 | nM | 7.84 |
| CHEMBL4875011 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4849134 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4867467 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4853179 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4867716 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4858463 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4874031 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4852513 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4853711 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4864576 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4870434 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4859351 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4847571 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4856366 | — | IC50 | = | 64.7 | nM | 7.19 |
| CHEMBL4854929 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL4859716 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL4871544 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL136106 | — | IC50 | = | 30000.0 | nM | 4.52 |