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Assay Detail

CHEMBL4815769

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387)
Type CELL-LINE
Organism Homo sapiens

Publication

An insight into the anticancer potential of carbamates and thiocarbamates of 10-demethoxy-10-methylaminocolchicine.
Krzywik J, Aminpour M, Janczak J, Maj E, Moshari M, Mozga W, Wietrzyk J, Tuszyński JA, Huczyński A.
Eur J Med Chem (2021) 215 : 113282 -113282
PubMed 33611191 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 8.29 9.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4846745 1 9.15
CHEMBL4870066 1 9.10
CHEMBL4855438 1 9.10
CHEMBL4877808 1 9.05
CHEMBL4857713 1 9.00
CHEMBL4878470 1 8.96
CHEMBL88059 1 8.80
CHEMBL4878929 1 8.74
CHEMBL4851979 1 8.33
CHEMBL4875098 1 8.15
CHEMBL4864567 1 8.10
CHEMBL4866269 1 8.04
CHEMBL4854676 1 8.01
CHEMBL107 COLCHICINE 4.0 1 7.96
CHEMBL4854459 1 7.95
CHEMBL4863822 1 7.81
CHEMBL4864443 1 7.46
CHEMBL4847983 1 6.91
CHEMBL53463 DOXORUBICIN 4.0 1 6.88

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4846745 IC50 = 0.7 nM 9.15
CHEMBL4870066 IC50 = 0.8 nM 9.10
CHEMBL4855438 IC50 = 0.8 nM 9.10
CHEMBL4877808 IC50 = 0.9 nM 9.05
CHEMBL4857713 IC50 = 1.0 nM 9.00
CHEMBL4878470 IC50 = 1.1 nM 8.96
CHEMBL88059 IC50 = 1.6 nM 8.80
CHEMBL4878929 IC50 = 1.8 nM 8.74
CHEMBL4851979 IC50 = 4.7 nM 8.33
CHEMBL4875098 IC50 = 7.0 nM 8.15
CHEMBL4864567 IC50 = 8.0 nM 8.10
CHEMBL4866269 IC50 = 9.2 nM 8.04
CHEMBL4854676 IC50 = 9.8 nM 8.01
CHEMBL107 COLCHICINE IC50 = 10.9 nM 7.96
CHEMBL4854459 IC50 = 11.3 nM 7.95
CHEMBL4863822 IC50 = 15.6 nM 7.81
CHEMBL4864443 IC50 = 35.0 nM 7.46
CHEMBL4847983 IC50 = 122.3 nM 6.91
CHEMBL53463 DOXORUBICIN IC50 = 131.5 nM 6.88