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Assay Detail

CHEMBL4815902

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Binding
Inhibition of Saccharomyces cerevisiae alpha-glucosidase assessed as reduction in PNP formation using alpha-PNPG as substrate incubated for 30 mins
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Saccharomyces cerevisiae
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

2,5-Disubstituted furan derivatives containing 1,3,4-thiadiazole moiety as potent α-glucosidase and E. coli β-glucuronidase inhibitors.
Li YS, He M, Zhou TS, Wang Q, He L, Wang SJ, Hu B, Wei B, Wang H, Cui ZN.
Eur J Med Chem (2021) 216 : 113322 -113322
PubMed 33652353 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 31 6.02 6.73

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4855744 1 6.73
CHEMBL4856885 1 6.65
CHEMBL4873138 1 6.62
CHEMBL4871420 1 6.54
CHEMBL4863059 1 6.28
CHEMBL4863560 1 6.21
CHEMBL4847913 1 6.19
CHEMBL4878357 1 6.19
CHEMBL4852334 1 6.18
CHEMBL4847185 1 6.17
CHEMBL4865641 1 6.14
CHEMBL4865610 1 6.11
CHEMBL4855437 1 6.08
CHEMBL4853563 1 6.06
CHEMBL4853254 1 6.04
CHEMBL4862791 1 5.94
CHEMBL4865652 1 5.87
CHEMBL4856705 1 5.80
CHEMBL4859250 1 5.78
CHEMBL4863771 1 5.74
CHEMBL4865828 1 5.73
CHEMBL4870977 1 5.71
CHEMBL4866822 1 5.60
CHEMBL4853304 1 5.56
CHEMBL4854113 1 5.53
CHEMBL4872286 1 4.96
CHEMBL4872425 1 -
CHEMBL404271 ACARBOSE 4.0 1 -
CHEMBL4872076 1 -
CHEMBL4851087 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4855744 IC50 = 186.0 nM 6.73
CHEMBL4856885 IC50 = 223.0 nM 6.65
CHEMBL4873138 IC50 = 239.0 nM 6.62
CHEMBL4871420 IC50 = 286.0 nM 6.54
CHEMBL4863059 IC50 = 526.0 nM 6.28
CHEMBL4863560 IC50 = 613.0 nM 6.21
CHEMBL4847913 IC50 = 646.0 nM 6.19
CHEMBL4878357 IC50 = 652.0 nM 6.19
CHEMBL4852334 IC50 = 658.0 nM 6.18
CHEMBL4847185 IC50 = 680.0 nM 6.17
CHEMBL4865641 IC50 = 728.0 nM 6.14
CHEMBL4865610 IC50 = 774.0 nM 6.11
CHEMBL4855437 IC50 = 823.0 nM 6.08
CHEMBL4853563 IC50 = 863.0 nM 6.06
CHEMBL4853254 IC50 = 903.0 nM 6.04
CHEMBL4862791 IC50 = 1139.0 nM 5.94
CHEMBL4865652 IC50 = 1347.0 nM 5.87
CHEMBL4856705 IC50 = 1568.0 nM 5.80
CHEMBL4859250 IC50 = 1668.0 nM 5.78
CHEMBL4863771 IC50 = 1813.0 nM 5.74
CHEMBL4865828 IC50 = 1854.0 nM 5.73
CHEMBL4870977 IC50 = 1935.0 nM 5.71
CHEMBL4866822 IC50 = 2504.0 nM 5.60
CHEMBL4853304 IC50 = 2736.0 nM 5.56
CHEMBL4854113 IC50 = 2952.0 nM 5.53
CHEMBL4872286 IC50 = 10970.0 nM 4.96
CHEMBL4872425 IC50 - -
CHEMBL404271 ACARBOSE IC50 = 516900.0 nM -
CHEMBL4872076 IC50 - -
CHEMBL4851087 IC50 - -
CHEMBL4852398 IC50 - -