Assay Detail
Binding
CHEMBL4815905
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Inhibition of Escherichia coli beta-glucosidase expressed in Escherichia coli BL21 (DE3) assessed as reduction in PNP formation using beta-PNPG as substrate incubated for 30 mins
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
2,5-Disubstituted furan derivatives containing 1,3,4-thiadiazole moiety as potent α-glucosidase and E. coli β-glucuronidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 6.23 | 7.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4854113 | — | — | 1 | 7.09 |
| CHEMBL1113 | AMOXAPINE | 4.0 | 1 | 7.08 |
| CHEMBL4847185 | — | — | 1 | 6.83 |
| CHEMBL4856705 | — | — | 1 | 6.67 |
| CHEMBL4865610 | — | — | 1 | 6.64 |
| CHEMBL4866822 | — | — | 1 | 6.61 |
| CHEMBL4852398 | — | — | 1 | 6.52 |
| CHEMBL4853304 | — | — | 1 | 6.51 |
| CHEMBL4871420 | — | — | 1 | 6.51 |
| CHEMBL4856885 | — | — | 1 | 6.47 |
| CHEMBL4870977 | — | — | 1 | 6.45 |
| CHEMBL4863059 | — | — | 1 | 6.42 |
| CHEMBL4853563 | — | — | 1 | 6.38 |
| CHEMBL4847913 | — | — | 1 | 6.37 |
| CHEMBL4851087 | — | — | 1 | 6.29 |
| CHEMBL4878357 | — | — | 1 | 6.28 |
| CHEMBL4873138 | — | — | 1 | 6.27 |
| CHEMBL4865641 | — | — | 1 | 6.26 |
| CHEMBL4852334 | — | — | 1 | 6.25 |
| CHEMBL4872425 | — | — | 1 | 6.16 |
| CHEMBL4872286 | — | — | 1 | 6.12 |
| CHEMBL4865828 | — | — | 1 | 6.10 |
| CHEMBL4853254 | — | — | 1 | 6.07 |
| CHEMBL4855437 | — | — | 1 | 6.04 |
| CHEMBL4863560 | — | — | 1 | 5.95 |
| CHEMBL4859250 | — | — | 1 | 5.94 |
| CHEMBL4872076 | — | — | 1 | 5.92 |
| CHEMBL4862791 | — | — | 1 | 5.90 |
| CHEMBL4855744 | — | — | 1 | 5.68 |
| CHEMBL4865652 | — | — | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4854113 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL1113 | AMOXAPINE | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL4847185 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL4856705 | — | IC50 | = | 212.0 | nM | 6.67 |
| CHEMBL4865610 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4866822 | — | IC50 | = | 247.0 | nM | 6.61 |
| CHEMBL4852398 | — | IC50 | = | 303.0 | nM | 6.52 |
| CHEMBL4853304 | — | IC50 | = | 307.0 | nM | 6.51 |
| CHEMBL4871420 | — | IC50 | = | 312.0 | nM | 6.51 |
| CHEMBL4856885 | — | IC50 | = | 341.0 | nM | 6.47 |
| CHEMBL4870977 | — | IC50 | = | 357.0 | nM | 6.45 |
| CHEMBL4863059 | — | IC50 | = | 379.0 | nM | 6.42 |
| CHEMBL4853563 | — | IC50 | = | 415.0 | nM | 6.38 |
| CHEMBL4847913 | — | IC50 | = | 425.0 | nM | 6.37 |
| CHEMBL4851087 | — | IC50 | = | 508.0 | nM | 6.29 |
| CHEMBL4878357 | — | IC50 | = | 526.0 | nM | 6.28 |
| CHEMBL4873138 | — | IC50 | = | 533.0 | nM | 6.27 |
| CHEMBL4865641 | — | IC50 | = | 551.0 | nM | 6.26 |
| CHEMBL4852334 | — | IC50 | = | 564.0 | nM | 6.25 |
| CHEMBL4872425 | — | IC50 | = | 695.0 | nM | 6.16 |
| CHEMBL4872286 | — | IC50 | = | 755.0 | nM | 6.12 |
| CHEMBL4865828 | — | IC50 | = | 796.0 | nM | 6.10 |
| CHEMBL4853254 | — | IC50 | = | 849.0 | nM | 6.07 |
| CHEMBL4855437 | — | IC50 | = | 923.0 | nM | 6.04 |
| CHEMBL4863560 | — | IC50 | = | 1129.0 | nM | 5.95 |
| CHEMBL4859250 | — | IC50 | = | 1143.0 | nM | 5.94 |
| CHEMBL4872076 | — | IC50 | = | 1205.0 | nM | 5.92 |
| CHEMBL4862791 | — | IC50 | = | 1265.0 | nM | 5.90 |
| CHEMBL4855744 | — | IC50 | = | 2081.0 | nM | 5.68 |
| CHEMBL4865652 | — | IC50 | = | 5367.0 | nM | 5.27 |
| CHEMBL1808316 | D-SACCHARIC ACID 1,4-LACTONE | IC50 | = | 67318.0 | nM | 4.17 |
| CHEMBL4863771 | — | IC50 | - | — | - |