Assay Detail
Functional
CHEMBL4815965
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against Leishmania infantum MHOM/MA(BE)/67 infected in mouse primary peritoneal macrophages treated 2 hrs post-infection and incubated for 5 days by Giemsa staining based microscopic analysis
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania infantum |
| Cell Type | Peritoneal macrophage |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of 3'-fluorinated 7-deazapurine nucleosides as antikinetoplastid agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 40 | 5.17 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4852417 | — | — | 1 | 7.05 |
| CHEMBL4871173 | — | — | 1 | 6.89 |
| CHEMBL4856247 | — | — | 1 | 6.43 |
| CHEMBL4870078 | — | — | 1 | 5.76 |
| CHEMBL4857373 | — | — | 1 | 5.69 |
| CHEMBL4849239 | — | — | 1 | 5.63 |
| CHEMBL4858295 | — | — | 1 | 5.55 |
| CHEMBL4878243 | — | — | 1 | 5.41 |
| CHEMBL4861248 | — | — | 1 | 5.30 |
| CHEMBL4873064 | — | — | 1 | 5.27 |
| CHEMBL4879131 | — | — | 1 | 5.22 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 5.13 |
| CHEMBL4859430 | — | — | 1 | 5.09 |
| CHEMBL4855327 | — | — | 1 | 4.90 |
| CHEMBL4849638 | — | — | 1 | 4.65 |
| CHEMBL4846004 | — | — | 1 | 4.63 |
| CHEMBL4860880 | — | — | 1 | 4.56 |
| CHEMBL72928 | — | — | 1 | 4.56 |
| CHEMBL4862263 | — | — | 1 | 4.49 |
| CHEMBL4867618 | — | — | 1 | 4.49 |
| CHEMBL4853463 | — | — | 1 | 4.42 |
| CHEMBL4854535 | — | — | 1 | 4.41 |
| CHEMBL420751 | — | — | 1 | 4.33 |
| CHEMBL4866903 | — | — | 1 | 4.29 |
| CHEMBL4863184 | — | — | 1 | - |
| CHEMBL4874598 | — | — | 1 | - |
| CHEMBL4852610 | — | — | 1 | - |
| CHEMBL4867811 | — | — | 1 | - |
| CHEMBL4871965 | — | — | 1 | - |
| CHEMBL4868788 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4852417 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4871173 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4856247 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4870078 | — | EC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL4857373 | — | EC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL4849239 | — | EC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL4858295 | — | EC50 | = | 2830.0 | nM | 5.55 |
| CHEMBL4878243 | — | EC50 | = | 3870.0 | nM | 5.41 |
| CHEMBL4861248 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4873064 | — | EC50 | = | 5340.0 | nM | 5.27 |
| CHEMBL4879131 | — | EC50 | = | 5950.0 | nM | 5.22 |
| CHEMBL125 | MILTEFOSINE | EC50 | = | 7470.0 | nM | 5.13 |
| CHEMBL4859430 | — | EC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL4855327 | — | EC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL4849638 | — | EC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL4846004 | — | EC50 | = | 23400.0 | nM | 4.63 |
| CHEMBL4860880 | — | EC50 | = | 27270.0 | nM | 4.56 |
| CHEMBL72928 | — | EC50 | = | 27500.0 | nM | 4.56 |
| CHEMBL4862263 | — | EC50 | = | 32500.0 | nM | 4.49 |
| CHEMBL4867618 | — | EC50 | = | 32500.0 | nM | 4.49 |
| CHEMBL4853463 | — | EC50 | = | 38400.0 | nM | 4.42 |
| CHEMBL4854535 | — | EC50 | = | 39300.0 | nM | 4.41 |
| CHEMBL420751 | — | EC50 | = | 46900.0 | nM | 4.33 |
| CHEMBL4866903 | — | EC50 | = | 50800.0 | nM | 4.29 |
| CHEMBL4865014 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4853520 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4869277 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4872128 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4871274 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4856223 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4853123 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4854963 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4878319 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4849363 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4868788 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4871965 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4867811 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4852610 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4874598 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4863184 | — | EC50 | > | 64000.0 | nM | - |