Assay Detail
ADMET
CHEMBL4815967
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Cytotoxicity against human MRC5 cells assessed as reduction in cell viability after 3 days by resazurin dye based fluorimetric analysis
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | MRC5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of 3'-fluorinated 7-deazapurine nucleosides as antikinetoplastid agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 39 | 5.12 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4871173 | — | — | 1 | 6.80 |
| CHEMBL4859430 | — | — | 1 | 6.12 |
| CHEMBL4857373 | — | — | 1 | 5.88 |
| CHEMBL4862263 | — | — | 1 | 5.62 |
| CHEMBL4858295 | — | — | 1 | 5.38 |
| CHEMBL72928 | — | — | 1 | 5.31 |
| CHEMBL4870078 | — | — | 1 | 5.26 |
| CHEMBL4849239 | — | — | 1 | 5.18 |
| CHEMBL4860880 | — | — | 1 | 5.15 |
| CHEMBL4878243 | — | — | 1 | 5.13 |
| CHEMBL4852417 | — | — | 1 | 4.86 |
| CHEMBL4867618 | — | — | 1 | 4.85 |
| CHEMBL4855327 | — | — | 1 | 4.77 |
| CHEMBL4879131 | — | — | 1 | 4.73 |
| CHEMBL4854535 | — | — | 1 | 4.70 |
| CHEMBL4873064 | — | — | 1 | 4.68 |
| CHEMBL4861248 | — | — | 1 | 4.66 |
| CHEMBL4856247 | — | — | 1 | 4.50 |
| CHEMBL4856223 | — | — | 1 | 4.39 |
| CHEMBL420751 | — | — | 1 | 4.38 |
| CHEMBL4866903 | — | — | 1 | - |
| CHEMBL4869277 | — | — | 1 | - |
| CHEMBL4849638 | — | — | 1 | - |
| CHEMBL4863184 | — | — | 1 | - |
| CHEMBL4874598 | — | — | 1 | - |
| CHEMBL4849363 | — | — | 1 | - |
| CHEMBL4852610 | — | — | 1 | - |
| CHEMBL4854963 | — | — | 1 | - |
| CHEMBL4867811 | — | — | 1 | - |
| CHEMBL4871965 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4871173 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4859430 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL4857373 | — | EC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL4862263 | — | EC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL4858295 | — | EC50 | = | 4140.0 | nM | 5.38 |
| CHEMBL72928 | — | EC50 | = | 4920.0 | nM | 5.31 |
| CHEMBL4870078 | — | EC50 | = | 5490.0 | nM | 5.26 |
| CHEMBL4849239 | — | EC50 | = | 6650.0 | nM | 5.18 |
| CHEMBL4860880 | — | EC50 | = | 7010.0 | nM | 5.15 |
| CHEMBL4878243 | — | EC50 | = | 7380.0 | nM | 5.13 |
| CHEMBL4852417 | — | EC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL4867618 | — | EC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL4855327 | — | EC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL4879131 | — | EC50 | = | 18600.0 | nM | 4.73 |
| CHEMBL4854535 | — | EC50 | = | 20200.0 | nM | 4.70 |
| CHEMBL4873064 | — | EC50 | = | 20900.0 | nM | 4.68 |
| CHEMBL4861248 | — | EC50 | = | 21700.0 | nM | 4.66 |
| CHEMBL4856247 | — | EC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL4856223 | — | EC50 | = | 40300.0 | nM | 4.39 |
| CHEMBL420751 | — | EC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL4871965 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4865014 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4853520 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4872128 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4853463 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4871274 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4853123 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4878319 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4846004 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4868788 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4866903 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4867811 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4854963 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4852610 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4849363 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4874598 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4863184 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4849638 | — | EC50 | > | 64000.0 | nM | - |
| CHEMBL4869277 | — | EC50 | > | 64000.0 | nM | - |