Assay Detail
Functional
CHEMBL4815974
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at P2Y14 (unknown origin) expressed in HEK293 cells assessed as reduction in cAMP production incubated for 30 mins by ADP-glo assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of 3-amide-5-aryl benzoic acid derivatives as novel P2Y<sub>14</sub>R antagonists with potential high efficiency against acute gouty arthritis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.51 | 8.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4436879 | — | — | 1 | 8.75 |
| CHEMBL1800685 | PPTN | — | 1 | 8.70 |
| CHEMBL4854775 | — | — | 1 | 8.66 |
| CHEMBL4858280 | — | — | 1 | 8.58 |
| CHEMBL4875670 | — | — | 1 | 8.53 |
| CHEMBL4857372 | — | — | 1 | 8.31 |
| CHEMBL4871413 | — | — | 1 | 8.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4436879 | — | IC50 | = | 1.77 | nM | 8.75 |
| CHEMBL1800685 | PPTN | IC50 | = | 1.98 | nM | 8.70 |
| CHEMBL4854775 | — | IC50 | = | 2.18 | nM | 8.66 |
| CHEMBL4858280 | — | IC50 | = | 2.63 | nM | 8.58 |
| CHEMBL4875670 | — | IC50 | = | 2.95 | nM | 8.53 |
| CHEMBL4857372 | — | IC50 | = | 4.85 | nM | 8.31 |
| CHEMBL4871413 | — | IC50 | = | 9.74 | nM | 8.01 |