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Assay Detail

CHEMBL4816099

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MDA-MB-231
Confidence 1 — Organism
Curated By Autocuration

Target

MDA-MB-231 (CHEMBL400)
Type CELL-LINE
Organism Homo sapiens

Publication

Discovery of novel N-benzylbenzamide derivatives as tubulin polymerization inhibitors with potent antitumor activities.
Zhu H, Li W, Shuai W, Liu Y, Yang L, Tan Y, Zheng T, Yao H, Xu J, Zhu Z, Yang DH, Chen ZS, Xu S.
Eur J Med Chem (2021) 216 : 113316 -113316
PubMed 33676300 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 7.43 7.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL67 COMBRETASTATIN A4 -1.0 1 7.82
CHEMBL4866085 1 7.57
CHEMBL4847422 1 7.54
CHEMBL4874842 1 7.54
CHEMBL4854479 1 7.54
CHEMBL4871248 1 7.54
CHEMBL4863424 1 7.52
CHEMBL1592124 1 7.51
CHEMBL4876931 1 7.26
CHEMBL4858784 1 7.24
CHEMBL4873405 1 7.24
CHEMBL4876731 1 7.21
CHEMBL4879382 1 7.07

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL67 COMBRETASTATIN A4 IC50 = 15.0 nM 7.82
CHEMBL4866085 IC50 = 27.0 nM 7.57
CHEMBL4847422 IC50 = 29.0 nM 7.54
CHEMBL4874842 IC50 = 29.0 nM 7.54
CHEMBL4854479 IC50 = 29.0 nM 7.54
CHEMBL4871248 IC50 = 29.0 nM 7.54
CHEMBL4863424 IC50 = 30.0 nM 7.52
CHEMBL1592124 IC50 = 31.0 nM 7.51
CHEMBL4876931 IC50 = 55.0 nM 7.26
CHEMBL4858784 IC50 = 57.0 nM 7.24
CHEMBL4873405 IC50 = 57.0 nM 7.24
CHEMBL4876731 IC50 = 62.0 nM 7.21
CHEMBL4879382 IC50 = 86.0 nM 7.07