Assay Detail
Binding
CHEMBL4816112
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of pig brain tubulin polymerisation incubated for 30 mins and measured every 2 mins for 60 mins by spectrophotometric method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Brain |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of novel N-benzylbenzamide derivatives as tubulin polymerization inhibitors with potent antitumor activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.46 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.58 |
| CHEMBL1592124 | — | — | 1 | 5.52 |
| CHEMBL4866085 | — | — | 1 | 5.52 |
| CHEMBL4853951 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2640.0 | nM | 5.58 |
| CHEMBL1592124 | — | IC50 | = | 2990.0 | nM | 5.52 |
| CHEMBL4866085 | — | IC50 | = | 3030.0 | nM | 5.52 |
| CHEMBL4853951 | — | IC50 | = | 6180.0 | nM | 5.21 |