Assay Detail
Functional
CHEMBL4816711
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MCF7 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure-activity relationship, in vitro and in vivo evaluation as antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.95 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4866837 | — | — | 1 | 8.77 |
| CHEMBL4875613 | — | — | 1 | 8.70 |
| CHEMBL4864923 | — | — | 1 | 8.11 |
| CHEMBL4870429 | — | — | 1 | 7.45 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4866837 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4875613 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4864923 | — | EC50 | = | 7.7 | nM | 8.11 |
| CHEMBL4870429 | — | EC50 | = | 35.2 | nM | 7.45 |
| CHEMBL428647 | PACLITAXEL | EC50 | = | 194.2 | nM | 6.71 |