Assay Detail
Functional
CHEMBL4817020
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Anti-necroptotic activity in human HT-29 cells assessed as inhibition of TNFalpha/Z-VAD-fmk (TSZ)-induced necroptosis by measuring increase in cell viability by celltiter-glo luminescent cell viability assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Ring closure strategy leads to potent RIPK3 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 5.73 | 6.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4861646 | — | — | 1 | 6.38 |
| CHEMBL4877986 | — | — | 1 | 6.37 |
| CHEMBL4877249 | — | — | 1 | 5.99 |
| CHEMBL4862270 | — | — | 1 | 5.99 |
| CHEMBL4876332 | — | — | 1 | 5.97 |
| CHEMBL4779280 | — | — | 1 | 5.82 |
| CHEMBL4866260 | — | — | 1 | 5.66 |
| CHEMBL4854299 | — | — | 1 | 5.65 |
| CHEMBL4846511 | — | — | 1 | 5.64 |
| CHEMBL4877658 | — | — | 1 | 5.42 |
| CHEMBL4852815 | — | — | 1 | 5.40 |
| CHEMBL4879079 | — | — | 1 | 4.48 |
| CHEMBL4853076 | — | — | 1 | - |
| CHEMBL4868642 | — | — | 1 | - |
| CHEMBL4870302 | — | — | 1 | - |
| CHEMBL4870972 | — | — | 1 | - |
| CHEMBL4867075 | — | — | 1 | - |
| CHEMBL4857598 | — | — | 1 | - |
| CHEMBL4858109 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4861646 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4877986 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4877249 | — | EC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL4862270 | — | EC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL4876332 | — | EC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL4779280 | — | EC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL4866260 | — | EC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL4854299 | — | EC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL4846511 | — | EC50 | = | 2280.0 | nM | 5.64 |
| CHEMBL4877658 | — | EC50 | = | 3810.0 | nM | 5.42 |
| CHEMBL4852815 | — | EC50 | = | 3960.0 | nM | 5.40 |
| CHEMBL4879079 | — | EC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL4853076 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL4868642 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL4870302 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL4870972 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL4867075 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL4857598 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL4858109 | — | EC50 | > | 20000.0 | nM | - |