Assay Detail
Binding
CHEMBL4817030
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BRAF (unknown origin) in presence of ATP by Lanthascreen TR-FRET assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase B-raf (CHEMBL5145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Ring closure strategy leads to potent RIPK3 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.15 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1880739 | GW305074X | — | 1 | 8.43 |
| CHEMBL4861646 | — | — | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1880739 | GW305074X | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4861646 | — | IC50 | = | 1362.0 | nM | 5.87 |