Assay Detail
Functional
CHEMBL4817059
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Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK-8 assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of diosgenin derivatives as apoptosis inducers through mitochondria-related pathways.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.73 | 4.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4863214 | — | — | 1 | 4.91 |
| CHEMBL4846997 | — | — | 1 | 4.90 |
| CHEMBL4862442 | — | — | 1 | 4.89 |
| CHEMBL2207420 | GLYCINE DIOSGENYL ESTER | — | 1 | 4.83 |
| CHEMBL4849388 | — | — | 1 | 4.79 |
| CHEMBL4870071 | — | — | 1 | 4.77 |
| CHEMBL4864611 | — | — | 1 | 4.73 |
| CHEMBL4864663 | — | — | 1 | 4.73 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.72 |
| CHEMBL4869795 | — | — | 1 | 4.58 |
| CHEMBL4858324 | — | — | 1 | 4.56 |
| CHEMBL412437 | DISOGENIN | — | 1 | 4.32 |
| CHEMBL2207424 | — | — | 1 | - |
| CHEMBL4853091 | — | — | 1 | - |
| CHEMBL4869601 | — | — | 1 | - |
| CHEMBL4857702 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4863214 | — | IC50 | = | 12280.0 | nM | 4.91 |
| CHEMBL4846997 | — | IC50 | = | 12650.0 | nM | 4.90 |
| CHEMBL4862442 | — | IC50 | = | 12880.0 | nM | 4.89 |
| CHEMBL2207420 | GLYCINE DIOSGENYL ESTER | IC50 | = | 14860.0 | nM | 4.83 |
| CHEMBL4849388 | — | IC50 | = | 16350.0 | nM | 4.79 |
| CHEMBL4870071 | — | IC50 | = | 16980.0 | nM | 4.77 |
| CHEMBL4864611 | — | IC50 | = | 18490.0 | nM | 4.73 |
| CHEMBL4864663 | — | IC50 | = | 18750.0 | nM | 4.73 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL4869795 | — | IC50 | = | 26090.0 | nM | 4.58 |
| CHEMBL4858324 | — | IC50 | = | 27660.0 | nM | 4.56 |
| CHEMBL412437 | DISOGENIN | IC50 | = | 48360.0 | nM | 4.32 |
| CHEMBL2207424 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4853091 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4869601 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4857702 | — | IC50 | > | 30000.0 | nM | - |