Assay Detail
Functional
CHEMBL4817102
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Antiproliferative activity against human BRCA-1 deficient HCC1937 cells assessed as reduction in cell growth incubated for 7 days by cell titer-glo assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCC1937 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel and potent PARP/PI3K dual inhibitors for the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.83 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4865059 | — | — | 1 | 6.54 |
| CHEMBL4858564 | — | — | 1 | 6.39 |
| CHEMBL4861171 | — | — | 1 | 6.30 |
| CHEMBL4856241 | — | — | 1 | 6.10 |
| CHEMBL4875356 | — | — | 1 | 5.97 |
| CHEMBL1922094 | APITOLISIB | 2.0 | 1 | 5.49 |
| CHEMBL4874038 | — | — | 1 | 5.45 |
| CHEMBL4859625 | — | — | 1 | 5.41 |
| CHEMBL4868711 | — | — | 1 | 5.34 |
| CHEMBL4853655 | — | — | 1 | 5.27 |
| CHEMBL521686 | OLAPARIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4865059 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4858564 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4861171 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4856241 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4875356 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL1922094 | APITOLISIB | IC50 | = | 3210.0 | nM | 5.49 |
| CHEMBL4874038 | — | IC50 | = | 3570.0 | nM | 5.45 |
| CHEMBL4859625 | — | IC50 | = | 3860.0 | nM | 5.41 |
| CHEMBL4868711 | — | IC50 | = | 4580.0 | nM | 5.34 |
| CHEMBL4853655 | — | IC50 | = | 5380.0 | nM | 5.27 |
| CHEMBL521686 | OLAPARIB | IC50 | > | 10000.0 | nM | - |