Assay Detail
Binding
CHEMBL4817108
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate measured after 2 hrs by ADP-glo plus luminescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL3130) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of novel and potent PARP/PI3K dual inhibitors for the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.46 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4871210 | — | — | 1 | 8.74 |
| CHEMBL4865059 | — | — | 1 | 8.57 |
| CHEMBL4868231 | — | — | 1 | 8.37 |
| CHEMBL4858564 | — | — | 1 | 8.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4871210 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4865059 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4868231 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL4858564 | — | IC50 | = | 6.8 | nM | 8.17 |